Computational and Mathematical Methods in Medicine

Research Article

[Retracted] Network Pharmacology-Based Study on the Active Component and Mechanism of the Anti-Non-Invasive and Invasive Bladder Urothelial Carcinoma Effects of Zhuling Jisheng Decoction

Table 3

KEGG pathway analysis. 93 frequent approaches of treating noninvasive and invasive BLCAs for KEGG are enhanced.
IDDescriptionGene ratioBg ratio value valueGene IDCount
hsa05161Hepatitis B14/54162/8016BCL2/JUN/CASP3/CASP8/PRKCA/FOS/IL-6/STAT1/PRKCB/BIRC5/E2F1/E2F2/CDK2/CCNA214
hsa04933AGE-RAGE signaling pathway in diabetic complications11/54100/8016BCL2/JUN/CASP3/PRKCA/VEGFA/MMP2/IL-6/STAT1/F3/CCL2/PRKCB11
hsa05167Kaposi sarcoma-associated herpes virus infection13/54186/8016PTGS2/JUN/CASP3/CASP8/VEGFA/FOS/IL-6/STAT1/CXCL2/E2F1/E2F2/CALM1/PPP3CA13
hsa04657IL-17 signaling pathway10/5494/8016PTGS2/JUN/CASP3/CASP8/FOS/IL-6/MMP1/CCL2/CXCL2/IL-410
hsa05163Human cytomegalovirus infection13/54225/8016PTGS2/CASP3/CASP8/PRKCA/VEGFA/IL-6/CCL2/PTGER3/PRKCB/E2F1/E2F2/CALM1/PPP3CA13
hsa04218Cellular senescence11/54160/8016IL-6/CDK1/CCNB1/CHEK2/E2F1/E2F2/CDK2/CCNA2/CHEK1/CALM1/PPP3CA11
hsa05170Human immunodeficiency virus 1 infection12/54212/8016BCL2/JUN/CASP3/CASP8/PRKCA/FOS/CDK1/PRKCB/CCNB1/CHEK1/CALM1/PPP3CA12
hsa04115p53 signaling pathway8/5472/8016BCL2/CASP3/CASP8/CDK1/CCNB1/CHEK2/CDK2/CHEK18
hsa04020Calcium signaling pathway11/54193/8016CHRM3/CHRM2/ADRB2/ADRA1D/PRKCA/ERBB2/PTGER3/PRKCB/ERBB3/CALM1/PPP3CA11
hsa05169Epstein-Barr virus infection11/54201/8016BCL2/JUN/CASP3/CASP8/IL-6/STAT1/PSMD3/E2F1/E2F2/CDK2/CCNA211
hsa05219Bladder cancer6/5441/8016VEGFA/MMP2/MMP1/ERBB2/E2F1/E2F26
hsa05031Amphetamine addiction7/5469/8016MAOB/JUN/PRKCA/FOS/PRKCB/CALM1/PPP3CA7
hsa04659Th17 cell differentiation8/54107/8016RXRA/JUN/FOS/IL-6/STAT1/AHR/IL-4/PPP3CA8
hsa04668TNF signaling pathway8/54112/8016PTGS2/JUN/CASP3/CASP8/FOS/IL-6/CCL2/CXCL28
hsa05206MicroRNAs in cancer12/54310/8016PTGS2/BCL2/CASP3/PRKCA/VEGFA/TP63/ERBB2/PRKCB/CYP1B1/E2F1/E2F2/ERBB312
hsa01521EGFR tyrosine kinase inhibitor resistance7/5479/8016BCL2/PRKCA/VEGFA/IL-6/ERBB2/PRKCB/ERBB37
hsa04110Cell cycle8/54124/8016CDK1/CCNB1/CHEK2/E2F1/E2F2/CDK2/CCNA2/CHEK18
hsa05166Human T-cell leukemia virus 1 infection10/54219/8016JUN/FOS/IL-6/CHEK2/E2F1/E2F2/CDK2/CCNA2/CHEK1/PPP3CA10
hsa05222Small cell lung cancer7/5492/8016PTGS2/RXRA/BCL2/CASP3/E2F1/E2F2/CDK27
hsa05323Rheumatoid arthritis7/5493/8016JUN/VEGFA/FOS/IL-6/MMP1/CCL2/CXCL27
hsa05162Measles8/54138/8016BCL2/JUN/CASP3/CASP8/FOS/IL-6/STAT1/CDK28
hsa01522Endocrine resistance7/5498/8016BCL2/JUN/FOS/MMP2/ERBB2/E2F1/E2F27
hsa05223Non-small cell lung cancer6/5466/8016RXRA/PRKCA/ERBB2/PRKCB/E2F1/E2F26
hsa04625C-type lectin receptor signaling pathway7/54104/8016PTGS2/JUN/CASP8/IL-6/STAT1/CALM1/PPP3CA7
hsa01524Platinum drug resistance6/5473/8016BCL2/CASP3/CASP8/ERBB2/BIRC5/TOP2A6
hsa05140Leishmaniasis6/5477/8016PTGS2/JUN/FOS/STAT1/PRKCB/IL-46
hsa04970Salivary secretion6/5490/80160.000215397CHRM3/ADRB2/ADRA1D/PRKCA/PRKCB/CALM16
hsa04370VEGF signaling pathway5/5459/80160.0003194330.000129578PTGS2/PRKCA/VEGFA/PRKCB/PPP3CA5
hsa04215Apoptosis—multiple species4/5432/80160.0003988470.000161792BCL2/CASP3/CASP8/BIRC54
hsa05205Proteoglycans in cancer8/54204/80160.0003988470.000161792CASP3/PRKCA/VEGFA/MMP2/ERBB2/CAV1/PRKCB/ERBB38
hsa04921Oxytocin signaling pathway7/54153/80160.0004440380.000180123PTGS2/JUN/PRKCA/FOS/PRKCB/CALM1/PPP3CA7
hsa05160Hepatitis C7/54155/80160.000467110.000189483RXRA/CASP3/CASP8/STAT1/E2F1/E2F2/CDK27
hsa04066HIF-1 signaling pathway6/54109/80160.0005197910.000210852BCL2/PRKCA/VEGFA/IL-6/ERBB2/PRKCB6
hsa04725Cholinergic synapse6/54112/80160.0005868990.000238075CHRM3/CHRM2/BCL2/PRKCA/FOS/PRKCB6
hsa04151PI3K-Akt signaling pathway10/54354/80160.0001044780.0006119440.000248234RXRA/CHRM2/BCL2/PRKCA/VEGFA/IL-6/ERBB2/ERBB3/CDK2/IL-410
hsa04726Serotonergic synapse6/54115/80160.0001127280.0006419220.000260395PTGS1/PTGS2/MAOB/CASP3/PRKCA/PRKCB6
hsa05164Influenza A7/54170/80160.0001304140.0007225670.000293108CASP3/CASP8/PRKCA/IL-6/STAT1/CCL2/PRKCB7
hsa04010MAPK signaling pathway9/54295/80160.0001355060.000728730.000295608JUN/CASP3/PRKCA/VEGFA/FOS/ERBB2/PRKCB/ERBB3/PPP3CA9
hsa05214Glioma5/5475/80160.0001386360.000728730.000295608PRKCA/PRKCB/E2F1/E2F2/CALM15
hsa05133Pertussis5/5476/80160.0001476460.0007382280.000299461JUN/CASP3/FOS/IL-6/CALM15
hsa05212Pancreatic cancer5/5476/80160.0001476460.0007382280.000299461VEGFA/STAT1/ERBB2/E2F1/E2F25
hsa05152Tuberculosis7/54180/80160.0001860860.0009082770.000368441BCL2/CASP3/CASP8/IL-6/STAT1/CALM1/PPP3CA7
hsa04621NOD-like receptor signaling pathway7/54181/80160.0001925750.000918090.000372422BCL2/JUN/CASP8/IL-6/STAT1/CCL2/CXCL27
hsa04114Oocyte meiosis6/54128/80160.0002032290.0009468640.000384094PGR/CDK1/CCNB1/CDK2/CALM1/PPP3CA6
hsa04926Relaxin signaling pathway6/54129/80160.0002120490.0009660020.000391857JUN/PRKCA/VEGFA/FOS/MMP2/MMP16
hsa04728Dopaminergic synapse6/54132/80160.0002403370.0010710650.000434476MAOB/PRKCA/FOS/PRKCB/CALM1/PPP3CA6
hsa04012ErbB signaling pathway5/5485/80160.0002503980.0010921620.000443034JUN/PRKCA/ERBB2/PRKCB/ERBB35
hsa05210Colorectal cancer5/5486/80160.0002645050.0011296560.000458243BCL2/JUN/CASP3/FOS/BIRC55
hsa04210Apoptosis6/54136/80160.0002825960.0011822880.000479593BCL2/JUN/CASP3/CASP8/FOS/BIRC56
hsa04915Estrogen signaling pathway6/54138/80160.000305810.0012538210.00050861PGR/BCL2/JUN/FOS/MMP2/CALM16
hsa04510Focal adhesion7/54199/80160.0003444290.0013844710.000561608BCL2/JUN/PRKCA/VEGFA/ERBB2/CAV1/PRKCB7
hsa04658Th1 and Th2 cell differentiation5/5492/80160.0003622660.0014156560.000574258JUN/FOS/STAT1/IL-4/PPP3CA5
hsa05203Viral carcinogenesis7/54201/80160.0003659990.0014156560.000574258JUN/CASP3/CASP8/CDK1/CDK2/CCNA2/CHEK17
hsa04912GnRH signaling pathway5/5493/80160.0003809060.0014460320.000586581JUN/PRKCA/MMP2/PRKCB/CALM15
hsa05224Breast cancer6/54147/80160.0004294810.0016007910.000649358PGR/JUN/FOS/ERBB2/E2F1/E2F26
hsa05226Gastric cancer6/54149/80160.0004616360.0016645290.000675213RXRA/BCL2/ERBB2/E2F1/E2F2/CDK26
hsa05215Prostate cancer5/5497/80160.000462820.0016645290.000675213BCL2/ERBB2/E2F1/E2F2/CDK25
hsa04923Regulation of lipolysis in adipocytes4/5455/80160.0004864210.0017192470.000697409PTGS1/PTGS2/ADRB2/PTGER34
hsa04914Progesterone-mediated oocyte maturation5/5499/80160.0005084460.0017666340.000716632PGR/CDK1/CCNB1/CDK2/CCNA25
hsa05134Legionellosis4/5457/80160.0005577940.0019057980.000773083CASP3/CASP8/IL-6/CXCL24
hsa05142Chagas disease (American trypanosomiasis)5/54102/80160.000583140.0019281260.000782141JUN/CASP8/FOS/IL-6/CCL25
hsa05146Amoebiasis5/54102/80160.000583140.0019281260.000782141CASP3/PRKCA/IL-6/PRKCB/CXCL25
hsa04620Toll-like receptor signaling pathway5/54104/80160.0006373320.0020738570.000841257JUN/CASP8/FOS/IL-6/STAT15
hsa04928Parathyroid hormone synthesis, secretion, and action5/54106/80160.0006952210.002226880.00090333RXRA/BCL2/PRKCA/FOS/PRKCB5
hsa05321Inflammatory bowel disease (IBD)4/5465/80160.0009187630.0028976380.001175422JUN/IL-6/STAT1/IL-44
hsa04720Long-term potentiation4/5467/80160.0010298490.0031987740.001297577PRKCA/PRKCB/CALM1/PPP3CA4
hsa05165Human papillomavirus infection8/54330/80160.0015051950.0046054480.001868192PTGS2/CASP3/CASP8/VEGFA/STAT1/E2F1/CDK2/CCNA28
hsa04971Gastric acid secretion4/5475/80160.0015694770.004731510.001919329CHRM3/PRKCA/PRKCB/CALM14
hsa04380Osteoclast differentiation5/54128/80160.0016230430.0048220840.00195607JUN/PPARG/FOS/STAT1/PPP3CA5
hsa04960Aldosterone-regulated sodium reabsorption3/5437/80160.001909820.0055142680.002236853NR3C2/PRKCA/PRKCB3
hsa05143African trypanosomiasis3/5437/80160.001909820.0055142680.002236853PRKCA/IL-6/PRKCB3
hsa04662B cell receptor signaling pathway4/5482/80160.0021814180.0062109830.002519474JUN/FOS/PRKCB/PPP3CA4
hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4/5489/80160.0029413310.0082599010.003350615JUN/FOS/STAT1/PPP3CA4
hsa05132Salmonella infection6/54214/80160.0029934120.0082925610.003363863BCL2/JUN/CASP3/CASP8/FOS/IL-66
hsa04024cAMP signaling pathway6/54216/80160.0031349750.0083964270.003405996CHRM2/ADRB2/JUN/FOS/PTGER3/CALM16
hsa04261Adrenergic signaling in cardiomyocytes5/54149/80160.003153780.0083964270.003405996ADRB2/ADRA1D/BCL2/PRKCA/CALM15
hsa04932Nonalcoholic fatty liver disease (NAFLD)5/54149/80160.003153780.0083964270.003405996RXRA/JUN/CASP3/CASP8/IL-65
hsa04713Circadian entrainment4/5497/80160.0040118340.0105439230.004277124PRKCA/FOS/PRKCB/CALM14
hsa05231Choline metabolism in cancer4/5498/80160.0041619020.0107998730.00438095JUN/PRKCA/FOS/PRKCB4
hsa04064NF-kappa B signaling pathway4/54102/80160.0048002270.0123005820.00498971PTGS2/BCL2/PRKCB/CXCL24
hsa04022cGMP-PKG signaling pathway5/54167/80160.005129590.0128570650.005215446ADRB2/ADRA1D/ADRA2A/CALM1/PPP3CA5
hsa04660T cell receptor signaling pathway4/54104/80160.0051428260.0128570650.005215446JUN/FOS/IL-4/PPP3CA4
hsa05014Amyotrophic lateral sclerosis (ALS)3/5457/80160.0065418740.016157640.006554319BCL2/CASP3/PPP3CA3
hsa05145Toxoplasmosis4/54112/80160.0066772990.0162957880.006610358BCL2/CASP3/CASP8/STAT14
hsa05202Transcriptional misregulation in cancer5/54186/80160.0080357340.01938030.007861585RXRA/PPARG/IL-6/RUNX1T1/CCNA25
hsa04919Thyroid hormone signaling pathway4/54119/80160.0082472010.019433060.007882987RXRA/PRKCA/STAT1/PRKCB4
hsa04935Growth hormone synthesis, secretion, and action4/54119/80160.0082472010.019433060.007882987PRKCA/FOS/STAT1/PRKCB4
hsa04152AMPK signaling pathway4/54120/80160.00848960.0195546970.007932329PPARG/ACACA/SLC2A4/CCNA24
hsa05135Yersinia infection4/54120/80160.00848960.0195546970.007932329JUN/FOS/IL-6/CCL24
hsa04924Renin secretion3/5469/80160.0110693250.0251029480.010182967ADRB2/CALM1/PPP3CA3
hsa05130Pathogenic Escherichia coli infection5/54202/80160.0112459510.0251029480.010182967JUN/CASP3/CASP8/FOS/IL-65
hsa04068FoxO signaling pathway4/54131/80160.0114698530.0251029480.010182967IL-6/CCNB1/SLC2A4/CDK24
hsa04650Natural killer cell-mediated cytotoxicity4/54131/80160.0114698530.0251029480.010182967CASP3/PRKCA/PRKCB/PPP3CA4
hsa05120Epithelial cell signaling in Helicobacter pylori infection3/5470/80160.011510620.0251029480.010182967JUN/CASP3/CXCL23
hsa04270Vascular smooth muscle contraction4/54132/80160.0117701780.0253988060.010302982ADRA1D/PRKCA/PRKCB/CALM14
hsa03320PPAR signaling pathway3/5476/80160.0143709840.0306880390.01244855RXRA/PPARG/MMP13
hsa05204Chemical carcinogenesis3/5482/80160.0176005080.037196950.015088878PTGS2/ADH1C/CYP1B13
hsa04911Insulin secretion3/5486/80160.0199609580.0416686820.016902829CHRM3/PRKCA/PRKCB3
hsa04934Cushing syndrome4/54155/80160.0201229240.0416686820.016902829AHR/E2F1/E2F2/CDK24
hsa04540Gap junction3/5488/80160.0212037420.0434676720.017632586PRKCA/CDK1/PRKCB3
hsa04310Wnt signaling pathway4/54160/80160.0223216820.0453063840.018378456JUN/PRKCA/PRKCB/PPP3CA4
hsa04630JAK-STAT signaling pathway4/54162/80160.0232409160.0467096850.018947703BCL2/IL-6/STAT1/IL-44
hsa00350Tyrosine metabolism2/5436/80160.0242448720.0482543570.019574296ADH1C/MAOB2