Development and Validation of Prediction Model for High Ovarian Response in In Vitro Fertilization-Embryo Transfer: A Longitudinal Study

Table 2

Difference analysis for the potential predictors of ovarian response in IVF-ET.

Variables, (%)		Total ()	HR group ()	NR group ()	Statistic
Baseline	Age, years,					0.010
	Smoking history				—	0.686
	Active smoking	5 (1.49)	3 (1.80)	2 (1.18)
	Passive smoking	48 (14.29)	26 (15.57)	22 (13.02)
	No	283 (84.23)	138 (82.63)	145 (85.80)
	Type of infertility					0.060
	Primary	130 (38.69)	73 (43.71)	57 (33.73)
	Secondary	206 (61.31)	94 (56.29)	112 (66.27)
	Pregnancy history					0.228
	No	132 (39.29)	71 (42.51)	61 (36.09)
	Yes	204 (60.71)	96 (57.49)	108 (63.91)
	BMI, kg/m^2,					0.734
	Age at menarche, years,					0.209
	Mean menstrual cycle, days,					0.002
	Duration of infertility, years,	3.00 (2.00, 4.00)	3.00 (2.00, 5.00)	3.00 (1.00, 4.00)		0.153
	AFC,	15.00 (12.00, 19.00)	19.00 (16.00, 22.00)	12.00 (10.00, 14.00)		<0.001
MC3	LH, mu/ml,	4.79 (3.54, 6.02)	4.87 (3.61, 6.01)	4.71 (3.32, 6.04)		0.784
	E2, pmol/L,	36.16 (26.26, 46.38)	35.23 (23.22, 45.70)	37.56 (27.80, 47.44)		0.057
	P, nmol/L,	0.40 (0.26, 0.59)	0.46 (0.31, 0.66)	0.32 (0.22, 0.48)		<0.001
	FSH, U/L,					0.022
	AMH, ng/ml,	3.68 (2.46, 5.25)	5.20 (4.19, 6.17)	2.69 (2.01, 3.34)		<0.001
	Endometrial thickness, mm,					0.425
HCG day	Dosing days of Gn, days,					0.393
	Initial dose of Gn, IU,					0.003
	Total dose of Gn, IU,					0.032
	Endometrial thickness, mm,					0.095
	LH, mu/mL,	0.95 (0.55, 1.87)	0.84 (0.53, 1.42)	1.15 (0.55, 2.14)		0.031
	E2, pmol/L,	2986.00 (2074.86, 4857.50)	4403.00 (2811.00, 6000.00)	2405.00 (1657.00, 3483.00)		<0.001
	P, nmol/L,	0.95 (0.67, 1.32)	1.16 (0.82, 1.56)	0.81 (0.57, 1.12)		<0.001

HR group: high response group; NR group: normal response group; BMI: body mass index; AFC: antral follicle count; MC3: menstrual cycle day 3; LH: luteinizing hormone; E2: estradiol; P: progesterone; FSH: follicle-stimulating hormone; AMH: anti-Müllerian hormone; HCG: human chorionic gonadotropin; Gn: gonadotropin; : ; : median and quartile; : measured the degree of correlation between two categorical variables; : compared the difference between the two groups; : represented the rank sum test for the comparison of two samples.