Computational and Mathematical Methods in Medicine / 2021 / Article / Tab 2

Research Article

Development and Validation of Prediction Model for High Ovarian Response in In Vitro Fertilization-Embryo Transfer: A Longitudinal Study

Table 2

Difference analysis for the potential predictors of ovarian response in IVF-ET.

Variables, (%)Total ()HR group ()NR group ()Statistic

BaselineAge, years, 0.010
Smoking history0.686
 Active smoking5 (1.49)3 (1.80)2 (1.18)
 Passive smoking48 (14.29)26 (15.57)22 (13.02)
 No283 (84.23)138 (82.63)145 (85.80)
Type of infertility0.060
 Primary130 (38.69)73 (43.71)57 (33.73)
 Secondary206 (61.31)94 (56.29)112 (66.27)
Pregnancy history0.228
 No132 (39.29)71 (42.51)61 (36.09)
 Yes204 (60.71)96 (57.49)108 (63.91)
BMI, kg/m2, 0.734
Age at menarche, years, 0.209
Mean menstrual cycle, days, 0.002
Duration of infertility, years, 3.00 (2.00, 4.00)3.00 (2.00, 5.00)3.00 (1.00, 4.00)0.153
AFC, 15.00 (12.00, 19.00)19.00 (16.00, 22.00)12.00 (10.00, 14.00)<0.001
MC3LH, mu/ml, 4.79 (3.54, 6.02)4.87 (3.61, 6.01)4.71 (3.32, 6.04)0.784
E2, pmol/L, 36.16 (26.26, 46.38)35.23 (23.22, 45.70)37.56 (27.80, 47.44)0.057
P, nmol/L, 0.40 (0.26, 0.59)0.46 (0.31, 0.66)0.32 (0.22, 0.48)<0.001
FSH, U/L, 0.022
AMH, ng/ml, 3.68 (2.46, 5.25)5.20 (4.19, 6.17)2.69 (2.01, 3.34)<0.001
Endometrial thickness, mm, 0.425
HCG dayDosing days of Gn, days, 0.393
Initial dose of Gn, IU, 0.003
Total dose of Gn, IU, 0.032
Endometrial thickness, mm, 0.095
LH, mu/mL, 0.95 (0.55, 1.87)0.84 (0.53, 1.42)1.15 (0.55, 2.14)0.031
E2, pmol/L, 2986.00 (2074.86, 4857.50)4403.00 (2811.00, 6000.00)2405.00 (1657.00, 3483.00)<0.001
P, nmol/L, 0.95 (0.67, 1.32)1.16 (0.82, 1.56)0.81 (0.57, 1.12)<0.001

HR group: high response group; NR group: normal response group; BMI: body mass index; AFC: antral follicle count; MC3: menstrual cycle day 3; LH: luteinizing hormone; E2: estradiol; P: progesterone; FSH: follicle-stimulating hormone; AMH: anti-Müllerian hormone; HCG: human chorionic gonadotropin; Gn: gonadotropin; : ; : median and quartile; : measured the degree of correlation between two categorical variables; : compared the difference between the two groups; : represented the rank sum test for the comparison of two samples.

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