Dysregulation of Circadian Clock Genes as Significant Clinic Factor in the Tumorigenesis of Hepatocellular Carcinoma

Figure 2

Differential expression analysis of circadian clock genes between HCC and normal tissues. (a, b) Box diagrams showing the expression levels of 13 circadian clock genes in tumor samples compared with normal samples in TCGA and ICGC. The values of the differential expressed four CCGs (CRY2, PER1, RORA, and TIMELESS) were >0.05. (c) The circadian clock genes showing a similar expression tendency in TCGA and ICGC. (d) Methylation difference between normal and tumor tissues. (e) Correlation between methylation and mRNA expression. (f) Correlation of copy number variation (CNV) with mRNA expression. (g) Venn diagram showing clock genes that were regulated by both methylation and CNV. (h) The interrelationship between circadian clock genes. TCGA: The Cancer Genome Atlas; ICGC: International Cancer Genome Consortium.

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