Dysregulation of Circadian Clock Genes as Significant Clinic Factor in the Tumorigenesis of Hepatocellular Carcinoma
Table 1
Univariate and multivariate analyses of clinicopathological characteristics for overall survival in HCC patients from the TCGA dataset ().
Variables
(%)
Univariate analysis
Multivariate analysis
HR (95% CI)
HR (95% CI)
Age
<60
152 (47.8%)
1 (reference)
>60
166 (52.2%)
1.173 (0.796-1.730)
0.421
Sex
Female
99 (31.1%)
1 (reference)
1 (reference)
Male
219 (68.9%)
0.804 (0.539-1.198)
0.284
0.864 (0.579-1.287)
0.472
TNM stage
I+II
237 (73.9%)
1 (reference)
1 (reference)
III+IV
83 (26.1%)
2.815 (1.909-4.151)
<0.001
1.522 (0.206-11.219)
0.68
Tumor grade
G1+G2
197 (61.9%)
1 (reference)
G3+G4
121 (38.1%)
1.077 (0.724-1.603)
0.713
T stage
T1+T2
237 (74.5%)
1 (reference)
1 (reference)
T3+T4
81 (25.5%)
2.839 (1.923-4.189)
<0.001
1.822 (0.247-13.464)
0.556
Note: characteristics with in the univariate analysis were further screened in the multivariate analysis. HR: hazard ratio; CI: confidence interval; TNM stage: tumor-node-metastasis stage; T stage: stage of tumor invasion.
