Dysregulation of Circadian Clock Genes as Significant Clinic Factor in the Tumorigenesis of Hepatocellular Carcinoma

Table 2

Univariate and multivariate analyses of clinicopathological characteristics for overall survival in HCC patients from the ICGC dataset ().

Variables	(%)	Univariate analysis		Multivariate analysis
		HR (95% CI)		HR (95% CI)
Age
<60	44 (19.0%)	1 (reference)
>60	187 (81.0%)	0.890 (0.426-1.862)	0.758
Sex
Female	61 (26.4%)	1 (reference)		1 (reference)
Male	170 (73.6%)	0.502 (0.268-0.940)	0.031	0.389 (0.203-0.744)	0.004
TNM stage
I+II	141 (61.0%)	1 (reference)		1 (reference)
III+IV	90 (39.0%)	2.492 (1.351-4.599)	0.003	3.003 (1.598-5.645)	<0.001

Note: characteristics with in the univariate analysis were further screened in the multivariate analysis. HR: hazard ratio; CI: confidence interval; TNM stage: tumor-node-metastasis stage.