Review Article

Deep Learning in Cancer Diagnosis and Prognosis Prediction: A Minireview on Challenges, Recent Trends, and Future Directions

Table 2

Summary of the studies for the prognosis/prediction of cancers.

PublicationType(s) of cancerType of dataMethodsPerformance

[50]Astrocytic tumorMicroarray gene datasetANN96.15% accuracy
[51]Breast cancerNuclear morphometric featuresANNsGood (>5 years) and bad (<5 years) prognoses
[52]Breast invasive carcinomaGene expression dataMultiomics neural networksImproved performance using more omics data
[53]Breast cancerTCGARandom forest, neural networkLog-rank
[54]Malignant melanomaCustom datasetNonlinear ANN modelANN model performs better than Cox model
[55]MultipleWHAS, SUPPORT, METABRIC, Rotterdam tumor bankDeep feedforward neural networkBetter prognostic accuracy than the clinical experts for the prognosis of nasopharyngeal carcinoma
[56]Glioblastoma multiformeTCGAPathway-associated sparse deep neural network,
[57]Breast cancerGene expression profile+copy number alteration profile+clinical dataMultimodal deep neural networkThe proposed method achieves better performance than the prediction methods with single-dimensional data and other existing approaches
[58]Hepatocellular carcinomaTCGADL-based model value =
Concordance
[59]Colorectal cancerImages of tumor tissue samplesCombined convolutional and recurrent architecturesPrediction with only small tissue areas (hazard ratio 2.3), tissue microarray spot (hazard ratio 1.67), and whole-slide level (hazard ratio 1.65)
[60]Ovarian cancerCT imagesCombined DL and Cox proportional hazards modelConcordance index was 0.713 and 0.694
[61]MultipleTCGAANN frameworkSame or better predictive accuracy compared to other methods
[62]MultipleWHAS, SUPPORT, & METABRICCox proportional hazards deep neural networkSuperior in predicting personalized treatment recommendations
[63]Lower-grade glioma and glioblastomaTCGACNNsMedian concordance
[64]MesotheliomaTCGA+French sourceCNNsConcordance index of 0.656 on TCGA cohort
[65]MultipleTCGA+Gene Expression Omnibus datasetDL-based modelFor both marker types, the specificity of normal whole blood was 100%