[Retracted] CY-09 Inhibits NLRP3 Inflammasome Activation to Relieve Pain via TRPA1

Figure 1

CY-09 relieves inflammatory pain and inflammatory cytokine production in mice. (a, b) Effects of CY-09 on LPS or formalin-induced thermal hyperalgesia and licking time in mice with inflammatory pain. Mock (saline) or CY-09 was i.p. injected into mice ( per group). 2 h after the last injection, LPS (10 ng/μL) was used via i.p. injection. After 5 h, mice were sacrificed by cervical dislocation and samples were collected. Thermal hyperalgesia was evaluated by the time course of the paw withdrawal latency at the indicated time points after injection using a hot plate apparatus. Licking time of each group of mice was observed and counted within 60 minutes. (c, d) Effect of CY-09 on LPS or formalin-induced inflammatory responses. Levels of IL-6, TNF-α, and IL-1β in footpad tissues were assessed by RT-PCR. , , and . Data showed .

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