Dissecting the Pathogenesis of Diabetic Retinopathy Based on the Biological ceRNA Network and Genome Variation Disturbance

Figure 4

Topological characteristics and functional analysis of key ceRNAs in DR progression. (a) The degree and BC distribution of mRNAs in the CLMN. (b) The degree and BC distribution of lncRNAs in the CLMN. (c) Comparison of node degree between all coding genes and lncRNAs in the CLMN. (d) Comparison of node degree between the hub coding genes and lncRNAs in the CLMN. (e) Comparison of BC between all coding genes and lncRNAs in the CLMN. (f) Comparison of BC between the hub coding genes and lncRNAs in the CLMN. (g) The regulating tendency of hub lncRNAs in regulating diabetes genes, DR genes, and common genes. (h) The regulating proportion of hub lncRNAs in regulating different genes. (i) The ceRNA interaction profile between the top 50 hub lncRNAs and coding genes. (j, k) Functional analysis of hub coding genes based on KEGG and GO.

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