In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility

Figure 7

Molecular dynamic simulation analysis of the wild-type and mutant (C669G, C606S, and D219V) variants in a 2000 ps simulation. Plots of potential energy (kcal/mol) for wild type (a), C669G (e), C606S (i), and D219V (m). Plots of the radius of gyration (Å) for wild type (b), C669G (f), C606S (j), and D219V (n). Cartoon putty demonstrations of ADAM33 structures: wild type (c), C669G (g), C606S (k), and D219V (o). Blue signifies the lowest value for -factor, and red is for the highest value. The size of the tube mirrors the value of the -factor (i.e., the thicker the tube is, the greater the -factor). A plot of the residue-based fluctuations (Å): wild type (d), C669G (h), C606S (l), and D219V (p).

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