Computational and Mathematical Methods in Medicine

Research Article

In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility

Table 2

Structural evaluations of detrimental mutants of ADAM33 protein by different online software.
SNP IDAASMutPred2 Score1I-MUTANT2.0MuPro
StabilityRI2StabilitydelG3
rs773091023P678L0.64Decreased5Increased0.11
rs764301730C671R0.93Decreased5Decreased-1
rs751597707C669G0.89Decreased8Decreased-2.02
rs368984072G661R0.84Decreased7Decreased-0.62
rs777553708C637Y0.62Decreased3Decreased-0.65
rs1334863089C631F0.91Decreased3Decreased-0.06
rs754867141C606S0.93Decreased7Decreased-1.47
rs754867141C606Y0.93Decreased3Decreased-1
rs915448220C573Y0.93Increased1Decreased-0.75
rs1432549895C519R0.93Decreased2Decreased-0.93
rs1262246273Y513C0.93Decreased6Decreased-1.14
rs1203116461P496L0.84Decreased8Decreased-0.23
rs757567846D483A0.84Decreased4Decreased-1.01
rs1424975479C482F0.93Decreased5Decreased-0.51
rs1165412077C482S0.93Decreased6Decreased-1.22
rs779669835R476C0.92Decreased4Decreased-0.33
rs748720838C475G0.92Decreased7Decreased-1.66
rs528261077G472V0.92Decreased3Decreased-0.07
rs1378161696C463Y0.92Decreased2Decreased-0.77
rs768654352G460R0.87Decreased7Decreased-0.63
rs1192357091C444S0.92Decreased6Decreased-1.29
rs1192357091C444Y0.90Decreased4Decreased-0.84
rs777252478C439Y0.92Decreased2Decreased-0.56
rs1321728445C431S0.92Decreased5Decreased-1.46
rs747255442G428C0.92Decreased4Decreased-0.12
rs776082098C420Y0.93Decreased3Decreased-1.05
rs751613984C388Y0.93Decreased4Decreased-0.95
rs1313175203C371Y0.64Decreased0Decreased-0.83
rs764090883C371R0.78Decreased2Decreased-0.8
rs1297854732C360R0.91Decreased5Decreased-1.06
rs1351880201D219V0.92Decreased3Decreased-0.62
1Scores higher than 0.5 indicate pathogenicity. 2RI stands for reliability index of prediction. 3delG values under zero designate protein destabilization.