In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility
Table 2
Structural evaluations of detrimental mutants of ADAM33 protein by different online software.
SNP ID
AAS
MutPred2 Score1
I-MUTANT2.0
MuPro
Stability
RI2
Stability
delG3
rs773091023
P678L
0.64
Decreased
5
Increased
0.11
rs764301730
C671R
0.93
Decreased
5
Decreased
-1
rs751597707
C669G
0.89
Decreased
8
Decreased
-2.02
rs368984072
G661R
0.84
Decreased
7
Decreased
-0.62
rs777553708
C637Y
0.62
Decreased
3
Decreased
-0.65
rs1334863089
C631F
0.91
Decreased
3
Decreased
-0.06
rs754867141
C606S
0.93
Decreased
7
Decreased
-1.47
rs754867141
C606Y
0.93
Decreased
3
Decreased
-1
rs915448220
C573Y
0.93
Increased
1
Decreased
-0.75
rs1432549895
C519R
0.93
Decreased
2
Decreased
-0.93
rs1262246273
Y513C
0.93
Decreased
6
Decreased
-1.14
rs1203116461
P496L
0.84
Decreased
8
Decreased
-0.23
rs757567846
D483A
0.84
Decreased
4
Decreased
-1.01
rs1424975479
C482F
0.93
Decreased
5
Decreased
-0.51
rs1165412077
C482S
0.93
Decreased
6
Decreased
-1.22
rs779669835
R476C
0.92
Decreased
4
Decreased
-0.33
rs748720838
C475G
0.92
Decreased
7
Decreased
-1.66
rs528261077
G472V
0.92
Decreased
3
Decreased
-0.07
rs1378161696
C463Y
0.92
Decreased
2
Decreased
-0.77
rs768654352
G460R
0.87
Decreased
7
Decreased
-0.63
rs1192357091
C444S
0.92
Decreased
6
Decreased
-1.29
rs1192357091
C444Y
0.90
Decreased
4
Decreased
-0.84
rs777252478
C439Y
0.92
Decreased
2
Decreased
-0.56
rs1321728445
C431S
0.92
Decreased
5
Decreased
-1.46
rs747255442
G428C
0.92
Decreased
4
Decreased
-0.12
rs776082098
C420Y
0.93
Decreased
3
Decreased
-1.05
rs751613984
C388Y
0.93
Decreased
4
Decreased
-0.95
rs1313175203
C371Y
0.64
Decreased
0
Decreased
-0.83
rs764090883
C371R
0.78
Decreased
2
Decreased
-0.8
rs1297854732
C360R
0.91
Decreased
5
Decreased
-1.06
rs1351880201
D219V
0.92
Decreased
3
Decreased
-0.62
1Scores higher than 0.5 indicate pathogenicity. 2RI stands for reliability index of prediction. 3delG values under zero designate protein destabilization.