Research Article
In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility
Table 3
Structural evaluations of detrimental mutants of ADAM33 protein by SNPeffect 4.0 web server.
| | SNP ID | AAS | TANGO | WALTS | LIMBO | FoldX |
| | rs773091023 | P678L | No effect | No effect | No effect | Not available | | rs764301730 | C671R | No effect | No effect | No effect | Not available | | rs751597707 | C669G | No effect | No effect | No effect | Not available | | rs368984072 | G661R | No effect | No effect | No effect | Not available | | rs777553708 | C637Y | No effect | No effect | No effect | Not available | | rs1334863089 | C631F | No effect | No effect | No effect | Not available | | rs754867141 | C606S | No effect | No effect | No effect | Not available | | rs754867141 | C606Y | No effect | No effect | No effect | Not available | | rs915448220 | C573Y | No effect | No effect | No effect | Not available | | rs1432549895 | C519R | No effect | No effect | No effect | Not available | | rs1262246273 | Y513C | No effect | No effect | No effect | Not available | | rs1203116461 | P496L | No effect | No effect | No effect | Not available | | rs757567846 | D483A | No effect | No effect | No effect | Not available | | rs1424975479 | C482F | No effect | No effect | No effect | Not available | | rs1165412077 | C482S | No effect | No effect | No effect | Not available | | rs779669835 | R476C | No effect | No effect | No effect | Not available | | rs748720838 | C475G | No effect | No effect | No effect | Not available | | rs528261077 | G472V | No effect | No effect | No effect | Not available | | rs1378161696 | C463Y | No effect | No effect | No effect | Not available | | rs768654352 | G460R | No effect | No effect | No effect | Not available | | rs1192357091 | C444S | No effect | No effect | No effect | Not available | | rs1192357091 | C444Y | No effect | Increases amyloid propensity | No effect | Not available | | rs777252478 | C439Y | No effect | No effect | No effect | Not available | | rs747255442 | G428C | No effect | No effect | No effect | Not available | | rs747255442 | G428C | No effect | No effect | No effect | Not available | | rs776082098 | C420Y | No effect | No effect | No effect | Not available | | rs751613984 | C388Y | No effect | Increases amyloid propensity | No effect | Reduce stability | | rs1313175203 | C371Y | No effect | No effect | No effect | Severely reduce stability | | rs764090883 | C371R | No effect | No effect | No effect | Severely reduce stability | | rs1297854732 | C360R | No effect | No effect | No effect | Reduce stability | | rs1351880201 | D219V | Increased aggregation tendency | Decreases amyloid propensity | No effect | Severely reduce stability |
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