Research Article
In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility
Table 4
Structural evaluations of detrimental mutants of ADAM33 protein by NetSurfP.2 web server.
| SNP ID | AAS | NetSurfP.2 | Wild class | Mutant class | RSA | ASA (A°) | Class alignment | Class alignment | RSA | ASA (A°) |
| rs773091023 | P678L | 24 | 33 | Buried | Exposed | 29 | 54 | rs764301730 | C671R | 12 | 16 | Buried | Buried | 20 | 47 | rs751597707 | C669G | 7 | 10 | Buried | Buried | 8 | 6 | rs368984072 | G661R | 6 | 5 | Buried | Buried | 16 | 36 | rs777553708 | C637Y | 3 | 4 | Buried | Buried | 4 | 9 | rs1334863089 | C631F | 6 | 9 | Buried | Buried | 6 | 12 | rs754867141 | C606S | 1 | 1 | Buried | Buried | 1 | 1 | rs754867141 | C606Y | 1 | 1 | Buried | Buried | 1 | 3 | rs915448220 | C573Y | 8 | 11 | Buried | Buried | 14 | 30 | rs1432549895 | C519R | 12 | 17 | Buried | Buried | 20 | 47 | rs1262246273 | Y513C | 24 | 51 | Buried | Buried | 16 | 22 | rs1203116461 | P496L | 13 | 18 | Buried | Buried | 19 | 29 | rs757567846 | D483A | 23 | 33 | Buried | Buried | 17 | 19 | rs1424975479 | C482F | 10 | 14 | Buried | Buried | 14 | 28 | rs1165412077 | C482S | 10 | 14 | Buried | Buried | 19 | 22 | rs779669835 | R476C | 23 | 52 | Buried | Buried | 18 | 25 | rs748720838 | C475G | 7 | 10 | Buried | Buried | 13 | 10 | rs528261077 | G472V | 51 | 40 | Exposed | Exposed | 48 | 74 | rs1378161696 | C463Y | 11 | 15 | Buried | Buried | 16 | 35 | rs768654352 | G460R | 30 | 23 | Exposed | Exposed | 42 | 97 | rs1192357091 | C444S | 8 | 11 | Buried | Buried | 17 | 20 | rs1192357091 | C444Y | 8 | 11 | Buried | Buried | 11 | 23 | rs777252478 | C439Y | 7 | 10 | Buried | Buried | 13 | 27 | rs1321728445 | C431S | 5 | 7 | Buried | Buried | 8 | 10 | rs747255442 | G428C | 70 | 55 | Exposed | Exposed | 61 | 85 | rs776082098 | C420Y | 3 | 5 | Buried | Buried | 7 | 15 | rs751613984 | C388Y | 8 | 12 | Buried | Buried | 11 | 24 | rs1313175203 | C371Y | 4 | 6 | Buried | Buried | 9 | 19 | rs764090883 | C371R | 4 | 6 | Buried | Buried | 12 | 28 | rs1297854732 | C360R | 15 | 21 | Buried | Exposed | 50 | 113 | rs1351880201 | D219V | 7 | 10 | Buried | Buried | 5 | 7 |
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RSA stands for relative solvent accessibility. ASA stands for absolute solvent accessibility.
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