In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility

Table 4

Structural evaluations of detrimental mutants of ADAM33 protein by NetSurfP.2 web server.

SNP ID	AAS	NetSurfP.2
		Wild class			Mutant class
		RSA	ASA (A°)	Class alignment	Class alignment	RSA	ASA (A°)
rs773091023	P678L	24	33	Buried	Exposed	29	54
rs764301730	C671R	12	16	Buried	Buried	20	47
rs751597707	C669G	7	10	Buried	Buried	8	6
rs368984072	G661R	6	5	Buried	Buried	16	36
rs777553708	C637Y	3	4	Buried	Buried	4	9
rs1334863089	C631F	6	9	Buried	Buried	6	12
rs754867141	C606S	1	1	Buried	Buried	1	1
rs754867141	C606Y	1	1	Buried	Buried	1	3
rs915448220	C573Y	8	11	Buried	Buried	14	30
rs1432549895	C519R	12	17	Buried	Buried	20	47
rs1262246273	Y513C	24	51	Buried	Buried	16	22
rs1203116461	P496L	13	18	Buried	Buried	19	29
rs757567846	D483A	23	33	Buried	Buried	17	19
rs1424975479	C482F	10	14	Buried	Buried	14	28
rs1165412077	C482S	10	14	Buried	Buried	19	22
rs779669835	R476C	23	52	Buried	Buried	18	25
rs748720838	C475G	7	10	Buried	Buried	13	10
rs528261077	G472V	51	40	Exposed	Exposed	48	74
rs1378161696	C463Y	11	15	Buried	Buried	16	35
rs768654352	G460R	30	23	Exposed	Exposed	42	97
rs1192357091	C444S	8	11	Buried	Buried	17	20
rs1192357091	C444Y	8	11	Buried	Buried	11	23
rs777252478	C439Y	7	10	Buried	Buried	13	27
rs1321728445	C431S	5	7	Buried	Buried	8	10
rs747255442	G428C	70	55	Exposed	Exposed	61	85
rs776082098	C420Y	3	5	Buried	Buried	7	15
rs751613984	C388Y	8	12	Buried	Buried	11	24
rs1313175203	C371Y	4	6	Buried	Buried	9	19
rs764090883	C371R	4	6	Buried	Buried	12	28
rs1297854732	C360R	15	21	Buried	Exposed	50	113
rs1351880201	D219V	7	10	Buried	Buried	5	7

RSA stands for relative solvent accessibility. ASA stands for absolute solvent accessibility.