Research Article
In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility
Table 5
Ligand-binding site prediction of ADAM33 protein, obtained from RaptorX binding server.
| | Domain | value | uGDT (GDT) | uSeqId (SeqId) | Pocket | Multiplicity | Ligand | Binding residues |
| | 1 (residues 199-414) | | | 205 (95) | 1 | 150 | ZN | A309 T310 V311 G312 L313 T342 H345 E346 H349 H355 A374 A375 A376 T377 | | 2 | 71 | CA | E213 D296 N407 |
| | 2 (residues 69-198) | | 52 (40) | 9 (7) | 1 | 9 | PO4 | E170 Q171 L172 L173 T174 | | 2 | 9 | KDO | L172 L173 T174 W175 K176 | | 3 | 6 | FTT | G135 S137 Y149 R151 E165 F167 M169 E170 Q171 | | 4 | 6 | FTT | W127 S137 S147 Y149 M169 L172 | | 5 | 5 | OES | P99 Q102 P103 Q117 R119 | | 6 | 3 | OES | R121 P124 D125 S143 |
| | 3 (residues 1-68) | | 23 (34) | 5 (7) | 1 | 1 | 7OD | L15 L19 T41 P42 |
| | 4 (residues 415-690) | | 182 (66) | 97 (35) | 1 | 16 | CA | L484 E486 D498 V499 | | 2 | 15 | CA | L419 N422 F424 E426 E429 D432 | | 3 | 5 | MAN | G480 D481 |
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ZN: zinc ion; CA: calcium ion; PO4: phosphate ion; KDO: 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid; FTT: 3-hydroxy-tetradecanoic acid; OES: N-octyl-2-hydroxyethyl sulfoxide; 7OD: (2E,5R)-5-hydroxy-2-methylhept-2-enoic acid; MAN: alpha-D-mannopyranose.
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