Research Article
In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility
Table 6
Prediction of phylogenetic conservation in ADAM33 protein using ConSurf server.
| | SNP ID | AAS | Conservation score | Buried/exposed | Structural/functional |
| | rs773091023 | P678L | 7 | Exposed | — | | rs764301730 | C671R | 8 | Buried | — | | rs751597707 | C669G | 8 | Buried | — | | rs368984072 | G661R | 8 | Exposed | Functional | | rs777553708 | C637Y | 8 | Buried | — | | rs1334863089 | C631F | 8 | Exposed | Functional | | rs754867141 | C606S | 8 | Buried | — | | rs754867141 | C606Y | 8 | Buried | — | | rs915448220 | C573Y | 9 | Buried | Structural | | rs1432549895 | C519R | 9 | Buried | Structural | | rs1262246273 | Y513C | 7 | Exposed | — | | rs1203116461 | P496L | 8 | Exposed | Functional | | rs757567846 | D483A | 9 | Exposed | Functional | | rs1424975479 | C482F | 9 | Buried | Structural | | rs1165412077 | C482S | 9 | Buried | Structural | | rs779669835 | R476C | 9 | Exposed | Functional | | rs748720838 | C475G | 9 | Buried | Structural | | rs528261077 | G472V | 8 | Exposed | Functional | | rs1378161696 | C463Y | 9 | Buried | Structural | | rs768654352 | G460R | 8 | Exposed | Functional | | rs1192357091 | C444S | 9 | Buried | Structural | | rs1192357091 | C444Y | 9 | Buried | Structural | | rs777252478 | C439Y | 9 | Buried | Structural | | rs1321728445 | C431S | 9 | Buried | Structural | | rs747255442 | G428C | 8 | Exposed | Functional | | rs776082098 | C420Y | 8 | Buried | — | | rs751613984 | C388Y | 9 | Buried | Structural | | rs1313175203 | C371Y | 9 | Buried | Structural | | rs764090883 | C371R | 9 | Buried | Structural | | rs1297854732 | C360R | 9 | Buried | Structural | | rs1351880201 | D219V | 9 | Exposed | Functional |
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“b” indicates buried residue, “e” indicates exposed residue, “f” indicates functional residue (highly conserved and exposed), and “s” indicates structural residue (highly conserved and buried).
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