In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility

Table 7

Validation results of 3D modeled ADAM33 protein and its variants using different tools.

Model name	ProSAweb score	Verify3D residues with 3D-1D	ERRAT quality factor	PROCHECK
				Most favored regions	Additional allowed regions	Generously allowed regions	Disallowed regions
ADAM33	-9.53	97.59%	95.09	86.0%	12.8%	0.5%	0.7%
D219V	-9.43	97.99%	93.03	88.2%	10.1%	0.7%	1.0%
C388Y	-9.54	95.98%	91.83	86.0%	12.0%	1.0%	1.0%
C444Y	-9.40	95.18%	88.13	83.8%	12.5%	2.0%	1.7%
C475G	-9.77	95.18%	93.87	87.9%	11.3%	0.5%	0.2%
C606S	-9.53	98.19%	92.85	86.5%	11.8%	0.7%	1.0%
C669G	-9.31	92.77%	92.54	86.5%	11.1%	0.5%	2.0%