Potential Diagnostic and Prognostic Values of CBX8 Expression in Liver Hepatocellular Carcinoma, Kidney Renal Clear Cell Carcinoma, and Ovarian Cancer: A Study Based on TCGA Data Mining

Table 5

Univariate and multivariate analyses of different parameters for overall survival, relapse-free survival, and disease-free survival in KIRC patients.

Carcinoma	Survival	Characteristics	Univariate analysis			Multivariate analysis
				HR	95% CI		HR	95% CI
KIRC	OS	CBX8 expression high vs. low	<0.001	2.5	1.9-3.5	<0.001	2.2	1.6-3
		Gender male vs. female	0.68	0.93	0.68-1.3
		Age, years ≥60 vs. <60	<0.001	1.8	1.3-2.5	0.063	1.4	0.98-1.9
		TNM stage III/IV vs. I/II	<0.001	4.3	3.1-5.9	<0.001	3.2	2.2-4.5
		Grade G3/G4 vs. G1/G2	<0.001	2.6	1.8-3.7	0.005	1.7	1.2-2.5
	RFS	CBX8 expression high vs. low	<0.001	2.4	1.6-3.7	0.010	1.7	1.1-2.6
		Gender male vs. female	0.058	1.5	0.99-2.3	0.093	1.4	0.94-2.2
		Age, years ≥60 vs. <60	0.27	1.2	0.85-1.8
		TNM stage III/IV vs. I/II	<0.001	6	3.9-9	<0.001	4.7	3-7.2
		Grade G3/G4 vs. G1/G2	<0.001	3.5	2.2-5.4	0.001	2.1	1.3-3.4
	DFS	CBX8 expression high vs. low	<0.001	2.3	1.7-3	<0.001	1.9	1.4-2.5
		Gender male vs. female	0.39	1.1	0.85-1.5
		Age, years ≥60 vs. <60	<0.001	1.7	1.3-2.3	0.036	1.4	1-1.8
		TNM stage III/IV vs. I/II	<0.001	4.4	3.3-5.9	<0.001	3.4	2.5-4.6
		Grade G3/G4 vs. G1/G2	<0.001	2.8	2-3.8	<0.001	1.9	1.3-2.6