[Retracted] Acupuncture Effect Assessment in APP/PS1 Transgenic Mice: On Regulating Learning-Memory Abilities, Gut Microbiota, and Microbial Metabolites

Table 2

List of relevant metabolites identified by VIP scores.

No	Compound	VIP scores	KEGG	M vs. C	A vs. M
1	2-Hydroxymyristic acid	2.3674	NA	↑	↓
2	Cortisol	2.2876	C00735	↓	↑
3	Costunolide	2.1317	NA	↓	↑
4	5-Fluorouridine	2.0918	C16633	↑	↓
5	Benzyl cinnamate	1.9261	NA	↑	↓
6	6-Hydroxymelatonin	1.9253	C05643	↑	↓
7	Cymarin	1.9074	NA	↑	↓
8	Pravastatin	1.858	C01844	↑	↓
9	Ascorbic acid	1.8468	C01041	↑	↓
10	Crotonic acid	1.8403	C01771	↓	↑
11	Testosterone enanthate	1.8348	C08157	↑	↓
12	D-Serine	1.8304	C00740	↓	↑
13	Gly-Tyr	1.8304	NA	↑	↓
14	Cholic acid	1.8283	C00695	↑	↓
15	Deoxycholic acid	1.8261	C04483	↑	↓
16	Cotinine	1.8094	NA	↑	↓
17	L-Methionine sulfoxide	1.7992	NA	↑	↓
18	Acetyl tributyl citrate	1.7963	NA	↓	↑
19	Asiatic acid	1.7772	NA	↑	↓
20	L(+)-Ornithine	1.7701	NA	↑	↓
21	Gallic acid	1.7472	C01424	↑	↓
22	Mephobarbital	1.74	C07829	↑	↓
23	Taurine	1.7381	C00245	↑	↓
24	Deoxyuridine	1.7271	C00526	↑	↓
25	5α-Dihydrotestosterone	1.7155	NA	↑	↓
26	Propionylcarnitine	1.7107	C03017	↑	↓
27	N6,N6,N6-Trimethyl-L-lysine	1.7059	C03793	↓	↑
28	Tributyl phosphate	1.6935	NA	↓	↑
29	Desthiobiotin	1.6798	C01909	↑	↓
30	Prolylyphenylalanine	1.6725	NA	↑	↓
31	Jasmonic acid	1.6723	C08491	↓	↑
32	Glycodeoxycholic acid	1.6494	C05464	↑	↓
33	N-Formylmethionine	1.6231	NA	↑	↓
34	Thymine	1.6229	C00178	↑	↓
35	Genistein 4'-O-glucuronide	1.6162	NA	↑	↓
36	Glu-Val-Phe	1.5995	NA	↑	↓
37	Meprobamate	1.5918	NA	↑	↓
38	herniarin	1.5889	C09268	↓	↑
39	Stearamide	1.5853	C13846	↓	↑
40	Uracil	1.5764	C00106	↑	↓
41	Kahweol	1.5601	NA	↓	↑
42	Linoleic acid	1.5531	C01595	↑	↓
43	Valylproline	1.5507	NA	↑	↓
44	D-Sphingosine	1.5441	NA	↑	↓
45	Eicosapentaenoic acid	1.5282	C06428	↑	↓
46	Alanyltyrosine	1.5281	NA	↑	↓
47	Monobutylphthalate	1.5274	NA	↓	↑
48	Hydroxyphenyllactic acid	1.5262	C01207	↑	↓
49	L-Phenylalanine	1.5259	C00079	↑	↓
50	L-Pyroglutamic acid	1.5225	C01879	↑	↑
51	Diisobutylphthalate	1.5224	NA	↓	↑
52	Taurodeoxycholic acid	1.5198	C05463	↓	↑
53	2-Methyl-S-benzothiazole	1.5025	NA	↓	↑
54	Coumarin	1.4947	C05851	↓	↑
55	Perillartine	1.4923	NA	↓	↑
56	Asiaticoside	1.4824	C15428	↑	↑
57	Oleanolic acid	1.4788	C17148	↑	↓
58	Nateglinide	1.4757	NA	↑	↓
59	DL-Glutamine	1.4374	C00303	↑	↑
60	N-Acetylaspartic acid	1.4348	C01042	↑	↓
61	N-Acetyl-L-leucine	1.433	C02710	↑	↓
62	Gluconolactone	1.4319	NA	↓	↑
63	5-Hydroxy-L-tryptophan	1.4087	NA	↓	↑
64	Limonene	1.4042	NA	↓	↑
65	Glu-Gln	1.394	NA	↓	↑
66	Dodecyl sulfate	1.392	C08031	↓	↑
67	Dihydrothymine	1.379	NA	↑	↓
68	Gabapentin	1.3722	D00332	↓	↑
69	Thiamine	1.3713	C00378	↓	↑
70	Arachidonic acid	1.3673	C00219	↑	↓
71	Alpha,alpha-Trehalose	1.3651	C01083	↑	↑
72	6-Methylquinoline	1.3557	NA	↑	↓
73	Daidzin	1.3546	C10216	↓	↑
74	Gly-Val	1.351	NA	↑	↓
75	N5-Acetylornithine	1.3466	NA	↑	↓
76	Benzothiazole	1.3405	NA	↑	↑
77	Uridine monophosphate (UMP)	1.328	C00105	↑	↓
78	L-Aspartic acid	1.3063	C00049	↓	↑
79	Crustecdysone	1.3018	NA	↓	↓
80	2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid	1.2957	NA	↓	↑
81	2,2,6,6-Tetramethyl-1-piperidinol (TEMPO)	1.2921	NA	↓	↑
82	Imazamox	1.2899	C18598	↑	↓
83	2,4-Quinolinediol	1.2814	C16716	↑	↓
84	5-Thymidylic acid	1.2799	C00364	↑	↓
85	Thymidine	1.2671	C00214	↑	↓
86	8-HETE	1.2615	C14776	↑	↓
87	N2,N2-Dimethylguanosine	1.2596	NA	↓	↑
88	p-Coumaraldehyde	1.257	NA	↓	↑
89	Pyridoxine	1.2569	NA	↓	↑
90	Glycyl-L-leucine	1.2534	C02155	↑	↓
91	L-Glutamic acid	1.2445	C00025	↓	↑
92	5-Hydroxytryptophan	1.2438	C01017	↓	↑
93	Neocnidilide	1.2399	NA	↑	↑
94	Isophorone	1.2268	C14743	↓	↑
95	6-Hydroxycaproic acid	1.2208	NA	↑	↑
96	Xanthosine	1.2103	C01762	↑	↓
97	Pentadecanoic acid	1.2077	C16537	↑	↓
98	Pachyrrhizin	1.2051	NA	↓	↑
99	Prolinamide	1.2024	C19781	↓	↑

The sequence of the metabolites indicates their importance for the contribution to the group separations. “↑” in M vs. C indicates that specific metabolites in the APP/PS1 model group are upregulated in comparison to the control group. “↓” in M vs. C indicates that specific metabolites in the APP/PS1 model group are downregulated in comparison the to control group. “↑” in A vs. M indicates that specific metabolites in the acupuncture treatment group are upregulated in comparison to the APP/PS1 model group. “↓” in A vs. M indicates that specific metabolites in the acupuncture treatment group are downregulated in comparison to the acupuncture treatment group. “” reveals the significant difference of metabolites abundance between the two groups determined by Student’s -test, : : : ; : .