Research Article

Identification of the Potential Molecular Mechanism of TGFBI Gene in Persistent Atrial Fibrillation

Table 1

Pathways enriched by TGFBI and its coexpression genes in AF patients.

TermCount valueEnriched genes

hsa05332: Graft versus host disease139.14E-08HLA-DQB1/HLA-A/HLA-C/HLA-B/HLA-DMB/HLA-E/HLA-DMA/HLA-G/HLA-F/HLA-DPA1/HLA-DPB1/CD28/HLA-DRA
hsa04612: Antigen processing and presentation191.13E-07HLA-DQB1/PDIA3/KIR2DS5/HLA-A/HLA-C/HLA-B/KIR2DS3/HLA-DMB/HLA-E/HLA-DMA/RFXANK/CD74/HLA-G/HLA-F/CD4/HLA-DPA1/HLA-DPB1/KIR2DL3/HLA-DRA
hsa05150: Staphylococcus aureus infection161.37E-07HLA-DQB1/C3AR1/C3/C1R/ITGB2/C1S/HLA-DMB/HLA-DMA/C1QA/C1QB/FCGR2B/HLA-DPA1/FCGR2A/CFI/HLA-DPB1/HLA-DRA
hsa04514: Cell adhesion molecules (CAMs)262.13E-07CLDN8/CLDN16/HLA-DQB1/ITGB2/HLA-DMB/HLA-DMA/CDH5/CLDN14/SDC3/VCAM1/CD4/HLA-DPB1/CD28/ICAM2/HLA-A/CD99/HLA-C/CLDN20/HLA-B/HLA-E/HLA-G/HLA-F/NCAM2/VCAN/HLA-DPA1/HLA-DRA
hsa04940: Type I diabetes mellitus142.35E-07HLA-DQB1/HLA-A/HLA-C/HLA-B/HLA-DMB/HLA-E/HLA-DMA/HLA-G/HLA-F/CPE/HLA-DPA1/HLA-DPB1/CD28/HLA-DRA
hsa05330: Allograft rejection133.89E-07HLA-DQB1/HLA-A/HLA-C/HLA-B/HLA-DMB/HLA-E/HLA-DMA/HLA-G/HLA-F/HLA-DPA1/HLA-DPB1/CD28/HLA-DRA
hsa05320: Autoimmune thyroid disease155.51E-07HLA-DQB1/HLA-A/HLA-C/HLA-B/HLA-DMB/HLA-E/HLA-DMA/HLA-G/HLA-F/IFNA4/HLA-DPA1/IFNA14/HLA-DPB1/HLA-DRA/CD28
hsa04145: Phagosome266.30E-07HLA-DQB1/C3/C1R/ITGB2/HLA-DMB/HLA-DMA/STX12/HLA-DPB1/THBS2/TUBA1B/ACTB/MRC1/NCF2/HLA-A/COLEC12/HLA-C/HLA-B/HLA-E/HLA-G/HLA-F/FCGR2B/CD209/HLA-DPA1/FCGR2A/CD14/HLA-DRA
hsa05416: Viral myocarditis151.85E-06ACTB/HLA-DQB1/HLA-A/ITGB2/HLA-C/HLA-B/HLA-DMB/HLA-E/HLA-DMA/HLA-G/HLA-F/HLA-DPA1/HLA-DPB1/HLA-DRA/CD28
hsa04512: ECM-receptor interaction171.93E-05COL4A2/COL4A1/COL3A1/ITGA1/COL5A2/VWF/LAMA4/LAMA3/GP6/CD44/COL6A5/COL6A3/COL1A2/COL6A1/LAMB1/THBS2/FN1
hsa04610: Complement and coagulation cascades148.99E-05F13B/C1QA/C7/VWF/C3AR1/C1QB/THBD/SERPINF2/C3/TFPI/SERPING1/C1R/CFI/C1S
hsa05152: Tuberculosis233.06E-04MRC1/HLA-DQB1/SPHK2/C3/CEBPG/TIRAP/ITGB2/HLA-DMB/HLA-DMA/RFXANK/CD74/TNFRSF1A/FCGR2B/CD209/IFNA4/FCER1G/HLA-DPA1/IFNA14/FCGR2A/PPP3CA/HLA-DPB1/CD14/HLA-DRA
hsa05133: Pertussis138.02E-04C1QA/C1QB/GNAI3/C3/IRF1/TIRAP/PYCARD/ITGB2/SERPING1/C1R/C1S/CASP1/CD14
hsa05166: HTLV-I infection288.39E-04HLA-DQB1/WNT16/NRP1/ADCY8/ITGB2/HLA-DMB/HLA-DMA/VCAM1/TNFRSF1A/CDKN2A/PPP3CA/HLA-DPB1/EGR1/FZD9/IL2RB/LTBR/HLA-A/HLA-C/HLA-B/HLA-E/FZD4/HLA-G/HLA-F/ETS2/PDGFRA/PDGFRB/HLA-DPA1/HLA-DRA
hsa04672: Intestinal immune network for IgA production109.65E-04HLA-DQB1/LTBR/HLA-DPA1/TNFSF13/HLA-DPB1/HLA-DMB/HLA-DMA/CXCL12/HLA-DRA/CD28
hsa04974: Protein digestion and absorption141.07E-03COL4A2/COL14A1/COL4A1/COL7A1/COL6A5/COL3A1/COL6A3/PRCP/COL1A2/COL15A1/COL6A1/CPB1/COL5A2/SLC7A7
hsa04670: Leukocyte transendothelial migration161.68E-03ACTB/CLDN16/CLDN8/MYL7/GNAI3/NCF2/CD99/ITGB2/CLDN20/MMP2/CXCL12/CLDN14/CDH5/VCAM1/RAP1B/MSN
hsa04151: PI3K-Akt signaling pathway332.83E-03FGFR1/FGFR4/COL3A1/GNG11/LPAR1/G6PC2/COL6A5/IL4R/IFNA4/COL6A3/CREB3L2/COL6A1/LAMB1/THBS2/CSF1R/FN1/IL2RB/COL4A2/COL4A1/ITGA1/FGF21/FGF20/COL5A2/VWF/GNGT1/LAMA4/LAMA3/GNB1/LPAR6/COL1A2/PDGFRA/PDGFRB/IFNA14
hsa04810: Regulation of actin cytoskeleton233.00E-03ACTB/FGFR1/MYL7/FGFR4/ARHGEF7/ITGA1/IQGAP2/ITGB2/ARPC5/FGF21/FGF20/IQGAP1/ARPC1B/PAK3/ARPC2/TIAM1/SCIN/PDGFRA/PDGFRB/CYFIP1/TMSB4X/MSN/FN1
hsa05322: Systemic lupus erythematosus173.01E-03HLA-DQB1/C7/HIST1H4L/C3/GRIN2A/C1R/C1S/H2AFJ/HLA-DMB/HLA-DMA/C1QA/C1QB/HLA-DPA1/FCGR2A/HLA-DPB1/HLA-DRA/CD28
hsa05200: Pathways in cancer363.61E-03DCC/FGFR1/WNT16/GNAI3/ADCY8/GNG11/LPAR1/MMP2/CXCL12/CDKN2A/LAMB1/TRAF5/TRAF4/CSF1R/FN1/FZD9/BMP4/PTGER2/COL4A2/COL4A1/PTGER4/EPAS1/LEF1/FGF21/FGF20/MECOM/FZD4/GNGT1/LAMA4/LAMA3/GNAQ/GNB1/LPAR6/RASSF1/PDGFRA/PDGFRB
hsa04510: Focal adhesion225.09E-03ACTB/MYL7/COL4A2/COL4A1/COL3A1/ITGA1/FLNB/COL5A2/VWF/LAMA4/LAMA3/PAK3/COL6A5/COL6A3/COL1A2/PDGFRA/COL6A1/PDGFRB/RAP1B/LAMB1/THBS2/FN1
hsa05310: Asthma75.44E-03HLA-DQB1/FCER1G/HLA-DPA1/HLA-DPB1/HLA-DMB/HLA-DMA/HLA-DRA
hsa00590: Arachidonic acid metabolism106.18E-03AKR1C3/GGT5/PLA2G4A/PTGIS/ALOX12B/GGT1/ALOX5/CBR3/LTC4S/PLA2G2F
hsa04611: Platelet activation151.30E-02ACTB/GNAI3/ADCY8/COL3A1/COL5A2/VWF/PLA2G4A/GP6/GNAQ/VAMP8/COL1A2/FCER1G/RAP1B/FCGR2A/LCP2
hsa05140: Leishmaniasis101.63E-02HLA-DQB1/NCF2/C3/HLA-DPA1/ITGB2/FCGR2A/HLA-DPB1/HLA-DMB/HLA-DMA/HLA-DRA
hsa04666: Fc gamma R-mediated phagocytosis111.76E-02ARPC1B/FCGR2B/SPHK2/ARPC2/SCIN/ASAP2/MARCKS/FCGR2A/INPP5D/ARPC5/PLPP3
hsa05169: Epstein-Barr virus infection141.77E-02HLA-DQB1/CD44/FCER2/VIM/HLA-A/HLA-C/HLA-DPA1/HLA-B/HLA-DPB1/HLA-E/TRAF5/HLA-G/HLA-DRA/HLA-F
hsa05323: Rheumatoid arthritis112.37E-02HLA-DQB1/CTSK/HLA-DPA1/ITGB2/TNFSF13/HLA-DPB1/HLA-DMB/HLA-DMA/CXCL12/HLA-DRA/CD28
hsa05321: Inflammatory bowel disease (IBD)92.47E-02MAF/HLA-DQB1/IL4R/HLA-DPA1/HLA-DPB1/HLA-DMB/IL21/HLA-DMA/HLA-DRA
hsa05168: Herpes simplex infection182.57E-02HLA-DQB1/C3/HLA-A/HLA-C/HLA-B/HLA-DMB/HLA-E/HLA-DMA/HLA-G/CD74/HLA-F/TNFRSF1A/IFNA4/HLA-DPA1/IFNA14/HLA-DPB1/TRAF5/HLA-DRA
hsa04380: Osteoclast differentiation143.00E-02NOX3/NCF2/NOX1/TNFRSF1A/CYBB/CTSK/LILRA1/FCGR2B/OSCAR/FCGR2A/PPP3CA/LCP2/CSF1R/TYROBP
hsa05146: Amoebiasis123.31E-02COL4A2/LAMA4/LAMA3/COL4A1/GNAQ/COL3A1/COL1A2/ITGB2/LAMB1/COL5A2/CD14/FN1
hsa04650: Natural killer cell mediated cytotoxicity133.84E-02CD244/TNFSF10/KIR2DS5/ICAM2/IFNA4/FCER1G/IFNA14/ITGB2/PPP3CA/KIR2DS3/KIR2DL3/LCP2/TYROBP
hsa04390: Hippo signaling pathway154.12E-02ACTB/BMP4/FZD9/WNT16/LEF1/ITGB2/WWTR1/FZD4/FRMD1/AFP/CRB1/ID2/ID1/RASSF1/TEAD4
hsa05145: Toxoplasmosis124.18E-02HLA-DQB1/TNFRSF1A/LAMA4/LAMA3/GNAI3/HLA-DPA1/ALOX5/HLA-DPB1/HLA-DMB/LAMB1/HLA-DMA/HLA-DRA
hsa04015: Rap1 signaling pathway194.43E-02ACTB/FGFR1/FGFR4/GNAI3/ADCY8/GRIN2A/ITGB2/LPAR1/FGF21/FGF20/GNAQ/ID1/TIAM1/PDGFRA/RAPGEF5/PDGFRB/RAP1B/LCP2/CSF1R
hsa04014: Ras signaling pathway204.66E-02FGFR1/FGFR4/GRIN2A/GNG11/FGF21/FGF20/RGL1/GNGT1/PLA2G4A/PAK3/GNB1/TIAM1/RASSF1/ETS2/PDGFRA/RAPGEF5/PDGFRB/RAP1B/PLA2G2F/CSF1R
hsa04360: Axon guidance134.97E-02DCC/NRP1/GNAI3/PLXNA1/EFNB2/CXCL12/EPHB1/SLIT2/SEMA5A/ROBO1/PAK3/UNC5D/PPP3CA