Circadian Clock Genes Are Correlated with Prognosis and Immune Cell Infiltration in Colon Adenocarcinoma

Table 2

Correlations of CRY2, NR1D1, and PER2 and gene markers on tumor-infiltrating cells in COAD (TIMER).

Description	Gene markers	COAD
		CRY2		NR1D1		PER2
		Cor	value	Cor	value	Cor	value
CD8+ T cell	CD8A	0.118				0.039	0.402
	CD8B	0.121				0.031	0.511
T cell (general)	CD3D	0.102				0.005	0.919
	CD3E	0.208				0.087	0.062
	CD2	0.122				0.054	0.245
B cell	CD19	0.194				0.130
	CD79A	0.268				0.169
Monocyte	CD86	0.228				0.093
	CD115 (CSF1R)	0.418				0.179
TAM	CCL2	0.244				0.026	0.575
	CD68	0.293				0.105
	IL10	0.132				-0.008	0.868
M1 macrophage	INOS (NOS2)	-0.238				-0.059	0.209
	IRF5	0.210				0.099
	COX2 (PTGS2)	0.028				0.087	0.062
M2 macrophage	CD163	0.314		-0.090	0.053	0.145
	VSIG4	0.255		-0.111		0.030	0.519
	MS4A4A	0.206		-0.180		0.047	0.313
Neutrophils	CD66b (CEACAM8)	-0.241		-0.033	0.480	-0.174
	CD11b (ITGAM)	0.336		-0.010	0.837	0.122
	CCR7	0.318		-0.011	0.807	0.181
Natural killer cell	KIR2DL1	-0.089	0.057	-0.158		-0.072	0.123
	KIR2DL3	0.041	0.383	-0.130		-0.027	0.562
	KIR2DL4	-0.025	0.586	-0.091	0.051	0.017	0.720
	KIR3DL1	0.023	0.621	-0.068	0.148	-0.009	0.853
	KIR3DL2	0.120		-0.080	0.088	0.061	0.190
	KIR3DL3	-0.048	0.307	-0.091	0.051	0.010	0.825
	KIR2DS4	0.024	0.607	-0.114		-0.048	0.305
Dendritic cell	HLA-DPB1	0.247		-0.072	0.126	0.004	0.934
	HLA-DQB1	0.112		-0.113		-0.042	0.365
	HLA-DRA	0.118		-0.158		-0.054	0.245
	HLA-DPA1	0.201		-0.129		0.021	0.661
	BDCA-1 (CD1C)	0.308		-0.102		0.146
	BDCA-4 (NRP1)	0.427		-0.002	0.970	0.218
	CD11c (ITGAX)	0.309		0.020	0.668	0.146
Th1	T-bet (TBX21)	0.197		-0.098		0.097
	STAT4	0.171		-0.226		0.148
	STAT1	0.184		-0.037	0.435	0.107
	IFN-g (IFNG)	-0.083	0.077	-0.133		-0.015	0.746
	TNF-a (TNF)	0.079	0.092	-0.064	0.172	0.015	0.745
Th2	GATA3	0.336		0.017	0.716	0.127
	STAT6	0.361		0.255		0.337
	STAT5A	0.375		0.170		0.232
	IL13	0.034	0.473	0.019	0.685	-0.042	0.375
Tfh	BCL6	0.495		0.172		0.283
	IL21	0.099		-0.096		0.042	0.365
Th17	STAT3	0.359		0.045	0.336	0.396
	IL17A	-0.161		-0.134		0.028	0.546
Treg	FOXP3	0.348		0.020	0.664	0.145
	CCR8	0.346		-0.039	0.401	0.209
	STAT5B	0.546		0.277		0.438
	TGFb (TGFB1)	0.358		0.045	0.340	0.088	0.060
T cell exhaustion	PD-1 (PDCD1)	0.173		-0.045	0.337	0.053	0.254
	CTLA4	0.170		-0.053	0.254	0.091	0.051
	LAG3	0.108		-0.046	0.327	0.049	0.291
	TIM-3 (HAVCR2)	0.220		-0.151		0.052	0.266
	GZMB	0.019	0.684	-0.163		-0.013	0.780

Note: .