Research Article
[Retracted] Hypoxia Tumor Microenvironment Activates GLI2 through HIF-1α and TGF-β2 to Promote Chemotherapy Resistance of Colorectal Cancer
Figure 3
Immunohistochemical staining done and normal versus hypoxia conditions were studied where tumorsphere cells from patients without any cancer-associated fibroblasts (CAFs) showed only modest effects. Hence, this further confirms that the CAFs in hypoxia coordinate synergistically to increase level of chemotherapy resistance.