[Retracted] The Role and Mechanism of SIRT6 in Regulating Phenotype Transformation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm

Table 2

Top 10 genes of DEGs in the SIRT6-knockout mice compared to the WT mice.

Gene symbol	Gene ID	Official full name	Gene function
Morc1	17450	MORC family CW-type zinc finger 1	This gene encodes the human homolog of mouse morc, and like the mouse protein, it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because the testis from knockout mice shows greatly increased numbers of apoptotic cells
Cps1	227231	Carbamoyl-phosphate synthase 1	The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation
Kynu	70789	Kynureninase	Kynureninase is a pyridoxal-5-phosphate- (pyridoxal-P-) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants
Fmo6	226565	Flavin-containing monooxygenase 6	This gene is a pseudogene, and the diseases associated with FMO6P include trimethylaminuria
Ttn	22138	Titin	This gene encodes a large abundant protein of striated muscle. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma
Pla2g3	237625	Phospholipase A2 group III	This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer’s disease
Itgad	381924	Integrin subunit alpha D	This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are composed of noncovalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11 kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants
Sfpq	71514	Splicing factor proline and glutamine rich	The diseases associated with SFPQ include renal cell carcinoma, Xp11-associated and dyslexia
Fcrls	80891	Fc receptor-like S, scavenger receptor	This gene belongs to a class of proteins that resemble Fc receptors. They are preferentially expressed by B lymphocytes. Unlike the classical Fc receptors, there is no strong evidence that suggests that FCRLs bind to the Fc portion of antibodies
Chrna1	11435	Cholinergic receptor nicotinic alpha 1 subunit	The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetylcholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified