[Retracted] The Role and Mechanism of SIRT6 in Regulating Phenotype Transformation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm

Table 3

The details of top 5 DEGs related to both of SIRT6 and AAA.

Gene symbol	Gene ID	Official full name	Gene function
KYNU	70789	Kynureninase	Kynureninase is a pyridoxal-5-phosphate- (pyridoxal-P-) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants
NPTX2	4885	Neuronal pentraxin 2	This gene encodes a member of the family of neuronal pentraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- (AMPA-) type glutamate receptors at established synapses, resulting in nonapoptotic cell death of dopaminergic nerve cells. Upregulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD
SCRG1	11341	Stimulator of chondrogenesis 1	Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie-responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration
GRK5	2869	G protein-coupled receptor kinase 5	This gene encodes a member of the guanine nucleotide-binding protein- (G protein-) coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs)
RGS5	8490	Regulator of G protein signaling 5	This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1-dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified