Study Subjects, HY stage Intervention Outcome measures Medication state in evaluation time M-Jadad scale Experimental group Control group Experimental group Control group Au 2022 [11 ] 15 15 1-3 Multidisciplinary rehabilitation 6 months Multidisciplinary rehabilitation 6 weeks MDS- UPDRS motor, ADL LED, etc. On 5 Yang 2022 [13 ] 30 30 1-3 Multidisciplinary rehabilitation 18 months Multidisciplinary rehabilitation 4 months MDS-UPDRS motor, ADL LED, etc. On 5 Mak 2021 [12 ] 33 31 1-3 Aerobic exercise 6 months Usual care 6 months MDS-UPDRS motor, ADL LED, etc. On 5 Tollar 2019 [20 ] 19 20 1-2 Multidisciplinary rehabilitation 2 years No exercise 2 years MDS-UPDRS ADL, LED, etc. On 4 Kolk 2019 [21 ] 65 65 1-2 Aerobic exercise 6 months Stretching and relaxation 6 months MDS-UPDRS motor, ADL LED, etc. On/off 6 Ferreira 2018 [22 ] 18 17 1-3 Resistance exercise 6 months No intervention 6 months MDS-UPDRS motor, ADL, etc. On 5 Kolk 2018 [23 ] 22 15 1-2 Aerobic exercise 6 months No intervention 6 months MDS-UPDRS motor, ADL, etc. Off 5 Frazzitta 2015 [24 ] 20 20 1-2 Multidisciplinary rehabilitation 2 years Usual care 2 years MDS-UPDRS motor, ADL LED, etc. Off 5 Cocros 2013 [25 ] 20 18 1-3 Resistance exercise 1 year Fitness count exercise 1 years MDS-UPDRS motor, LED, etc On/off 6 Frazzitta 2012 [24 ] 25 25 3 Multidisciplinary rehabilitation 1 year Usual care 1 year MDS-UPDRS motor, ADL, LED, etc On 4