Review Article

The Application of Antimicrobial Photodynamic Therapy (aPDT) in the Treatment of Peri-Implantitis

Table 1

Clinical peri-implant parameters of subjects in randomized clinical trials comparing antibacterial photodynamic therapy with mechanical irrigation debridement for peri-implantitis treatment.

AuthorsPopulationTest groupControl groupMeasures or percentages
Test groupControl group

1. Romeo et al. [10]Individuals: 40
Implants: 123
Control: 59
Test: 63
Ultrasonic debridement and air polishing with a micronized glycine powder
Implant debridement at sites with PD ≥4 mm was done with carbon fiber-reinforced plastic curettes
Laser-assisted antimicrobial photodynamic therapy based on the HELBO protocol at implant sites with PD ≥4 mm
Piezoelectric ablator in combination with a special nonmetal tip
Implant debridement at sites with PD ≥4 mm was done with carbon fiber-reinforced plastic curettes
PD: 5 mm; 3 mm; 2 mm; and 2 mm
PLI: 60%; 11%; 17%; and 17%
BOP: 100%; 20%; 10%; and 0%
Analyses at baseline and 6, 12, and 24 weeks
PD: 5 mm; 3 mm; 2 mm; and 3 mm
PLI: 62%; 12%; 21%; and 25%
BOP: 100%; 35%; 20%; and 10%
Analyses at baseline and 6, 12, and 24 weeks
2. Rakašević et al. [11]Individuals: 40
Implants: 52
Control: 25
Test: 27
Photodynamic therapy0.1% chlorhexidine gel followed by saline irrigationPD: and
CAL: and
BOP: 28% and 5%
Analyses at baseline and 3 mon
PD: and
CAL: and
BOP: 24% and12%
Analyses at baseline and 3 mon
3. Schär et al. [12]Individuals: 40
Implants: 107
Control: 37
Test: 70
Photodynamic therapy (PDT)Local drug delivery (LDD)PD: ; ; and
PLI: ; ; and
BOP: ; ; and
Analyses at baseline, 3 mon, and 6 mon
PD: ; ; and
PLI: ; ; and
BOP: ; ; and
Analyses at baseline, 3 mon, and 6 mon
4. Albaker et al. [13]Individuals: 24
Implants: 24
Control: 13
Test: 11
Antimicrobial photodynamic therapy (aPDT) and open flap debridement (OFD)Open flap debridement (OFD)PI: , , and
BOP: , , and
PD: , , and
CBL: , , and
Analyses at baseline and 6 and12 mon
PI: , , and
BOP: , , and
PD: , , and
CBL: , , and
Analyses at baseline and 6 and 12 mon
5. Alqahtani et al. [14]Individuals: 98
Implants: 98
Control: 49
Test: 49
Mechanical debridement and photodynamic therapyMechanical debridementTest 1: cigarette smokers
PI: , , and
BOP: , , and
PD: , , and
CBL: , , and
Test 2: waterpipe smokers
PI: , , and
BOP: , , and
PD: , ,
CBL: , ,
Test 3: never smokers
PI: , , and
BOP: , , and
PD: , , and
CBL: , , and
Analyses at baseline and 3 and 6 mon
Control 1: cigarette smokers
PI: , , and
BOP: , , and
PD: , , and
CBL: , , and
Control 2: waterpipe smokers
PI: , , and
BOP: , , and
PD: , , and
CBL: , , and
Control 3: never smokers
PI: , , and
BOP: , , and
PD: , , and
CBL: , , and
Analyses at baseline and 3 and 6 mon
6. Ohba et al. [15]Individuals:21
Implants: 25
Control: 13
Test: 12
Antimicrobial photodynamic therapyIrrigationBOP: 83.3% and 83.3%
PI: and
Analyses at baseline and after treatment
BOP: 92.3% and 84.6%
PI: and
Analyses at baseline and after treatment
7. Karimi et al. [16]Individuals:10
Implants: 30
Control: 15
Test: 15
Closed surface scaling and photodynamic therapyClosed surface scalingPD: , , and
CAL: 7.36 ± 1.57, ,
Analyses at baseline and 1.5 and 3 mon
PD: , , and
CAL: , , and
Analyses at baseline and 1.5 and 3 mon
8. Almohareb et al. [17]Individuals: 40
Implants: 79 Control: 36
Test: 43
Photodynamic therapy and mechanical debridementMechanical debridementPD: , , and
BOP: , , and
Analyses at baseline and 6 and 12 mon
PD: , , and
BOP: , , and
Analyses at baseline and 6 and 12 mon
9. Al Rifaiy et al. [18]Individuals: 38
Implants: 65
Control: 27
Test: 38
Photodynamic therapy and mechanical debridementMechanical debridementPI: and
BOP: and
PD: and
Analyses at baseline and 12 weeks
PI: and
BOP: and
PD: and
Analyses at baseline and 12 weeks
10. Abduljabbar [19]Individuals: 60
Implants: 60
Control: 30
Test: 30
Photodynamic therapy and mechanical debridementMechanical debridementPD: , , and
BOP: , , and
Analyses at baseline and 3 and 6 mon
PD: , , and
BOP: , , and
Analyses at baseline and 3 and 6 mon