Research Article

In Silico Exploration of Novel Tubulin Inhibitors: A Combination of Docking and Molecular Dynamics Simulations, Pharmacophore Modeling, and Virtual Screening

Figure 8

The generated pharmacophore model in the colchicine binding site of tubulin. (a) Pharmacophore features are color-coded: purple, two hydrogen bond donor features (F1& F2: Don); orange, one aromatic feature (F3: Aro); green, one hydrophobic feature (F4: Hyd). (b) 3D spatial relationship and distance between pharmacophore features (Å).