Weighted Gene Coexpression Network Analysis Identified IL2/STAT5 Signaling Pathway as an Important Determinant of Peri-Implantitis

Table 1

List of top 20 differentially expressed genes.

Gene	Description		value	FDR
BT_HI-vs-BT_PI
ZMPSTE24	Zinc metallopeptidase STE24	0.05436861	0.000425	0.418
TUBB4B	Tubulin beta 4B class IVb	0.067058028	0.000776	0.418
EIF3M	Eukaryotic translation initiation factor 3 subunit M	0.163804868	0.000305	0.418
RAB10	RAB10, member RAS oncogene family	0.144274808	0.000823	0.418
SF3A3	Splicing factor 3a subunit 3	0.040577086	0.001089	0.418
AP1G1	Adaptor related prot	0.056817586	0.001125	0.418
C20orf203	Chromosome 20 open reading frame 203	-0.129391728	0.000552	0.418
MIR15B	microRNA 15b	-0.141409803	0.000692	0.418
MIR214	microRNA 214	-0.115661557	0.000828	0.418
MIR99A	microRNA 99a	-0.073109217	0.001108	0.418
OCIAD1	OCIA domain containing 1	0.123431672	0.001013	0.418
CAV1	Caveolin 1	0.093133672	0.00071	0.418
BRK1	BRICK1 subunit of SCAR/WAVE actin nucleating complex	0.065658554	0.000527	0.418
PPP6C	Protein phosphatase 6 catalytic subunit	0.03378179	0.000684	0.418
PSMB3	Proteasome subunit beta 3	0.135521691	0.000908	0.418
PSMD10	Proteasome 26S subunit, non-ATPase 10	-0.152847334	0.000283	0.418
HIST1H2BG	Histone cluster 1 H2B family member g	0.112335029	0.000385	0.418
SNRPG	Small nuclear ribonucleoprotein polypeptide G	0.149342222	0.000241	0.418
DCTN5	Dynactin subunit 5	0.119709276	0.000526	0.418
CAPZA1	Capping actin protein of muscle Z-line subunit alpha 1	0.145481101	0.000343	0.418
GT_HI-vs-GT_PI
NEFM	Neurofilament, medium polypeptide	-1.4062788	0.00000032	0.0106
MAPT	Microtubule associated protein tau	-1.83338262	0.00000206	0.0246
MERTK	MER proto-oncogene, tyrosine kinase	1.01973984	0.00000295	0.0246
MRC1	Mannose receptor, C type 1	1.01068439	0.00000588	0.029
GLIPR2	GLI pathogenesis related 2	0.86823054	0.00000688	0.029
SLC2A3	Solute carrier family 2 member 3	1.26464786	0.00000736	0.029
SLCO2B1	Solute carrier organic anion transporter family member 2B1	0.84589762	0.00000911	0.029
SRPX2	Sushi repeat containing protein, -linked 2	1.27391664	0.00000938	0.029
CD14	CD14 molecule	1.33965561	0.00000996	0.029
MSR1	Macrophage scavenger receptor 1	1.17709016	0.00001044	0.029
C1QB	Complement C1q B chain	0.83761875	0.00001224	0.0313
STAC2	SH3 and cysteine rich domain 2	-1.18651859	0.00001325	0.0313
CHRNA3	Cholinergic receptor nicotinic alpha 3 subunit	-0.94702121	0.00001433	0.0313
CTGF	Connective tissue growth factor	1.32968345	0.00001505	0.0313
CASP10	Caspase 10	0.66524239	0.00001683	0.033
TLR4	Toll like receptor 4	1.40463223	0.00001948	0.036
MS4A6A	Membrane spanning 4-domains A6A	0.91872666	0.00002886	0.0494
C3AR1	Complement component 3a receptor 1	1.07948921	0.00003202	0.0494
CMAHP	Cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	0.79185305	0.00003378	0.0494
SRGN	Serglycin	1.37684391	0.00003424	0.0494