Weighted Gene Coexpression Network Analysis Identified IL2/STAT5 Signaling Pathway as an Important Determinant of Peri-Implantitis

Table 2

List of top 10 enriched GO terms and pathways.

GO	Category	Description	Count	%	0 ()	0 ()
BT_HI-vs-BT_PI
R-HSA-8953897	Reactome gene sets	Cellular responses to external stimuli	105	5.1	-15.97	-11.66
hsa04141	KEGG pathway	Protein processing in endoplasmic reticulum	46	2.23	-12.45	-9.03
GO:0006888	GO biological processes	ER to Golgi vesicle-mediated transport	54	2.62	-12.3	-8.94
R-HSA-6798695	Reactome gene sets	Neutrophil degranulation	86	4.18	-10.54	-7.42
R-HSA-5619115	Reactome gene sets	Disorders of transmembrane transporters	43	2.09	-9.82	-6.99
GO:0048514	GO biological processes	Blood vessel morphogenesis	105	5.1	-8.45	-5.95
GO:0006412	GO biological processes	Translation	108	5.25	-8.39	-5.91
GO:0044257	GO biological processes	Cellular protein catabolic process	110	5.34	-7.33	-5.06
R-HSA-72766	Reactome gene sets	Translation	52	2.53	-6.6	-4.44
GO:0060627	GO biological processes	Regulation of vesicle-mediated transport	81	3.93	-6.57	-4.42
GT_HI-vs-GT_PI
GO:0002274	GO biological processes	Myeloid leukocyte activation	194	8.1	-45.73	-41.42
GO:0046649	GO biological processes	Lymphocyte activation	200	8.35	-40.59	-36.88
GO:0040017	GO biological processes	Positive regulation of locomotion	162	6.76	-33.22	-29.8
GO:0050900	GO biological processes	Leukocyte migration	143	5.97	-31.7	-28.56
GO:0001568	GO biological processes	Blood vessel development	183	7.64	-29.38	-26.44
GO:0043062	GO biological processes	Extracellular structure organization	124	5.18	-28.7	-25.81
GO:0001816	GO biological processes	Cytokine production	179	7.47	-25.89	-23.11
R-HSA-109582	Reactome gene sets	Hemostasis	147	6.14	-23.42	-20.68
GO:0002764	GO biological processes	Immune response-regulating signaling pathway	153	6.39	-22.13	-19.41
GO:0030029	GO biological processes	Actin filament-based process	164	6.84	-21.6	-18.9