Weighted Gene Coexpression Network Analysis Identified IL2/STAT5 Signaling Pathway as an Important Determinant of Peri-Implantitis

Table 3

Enrichment analysis results of modules.

Module	GO	Description	()
kMEblack	GO:0002250	Adaptive immune response	-7.69
	GO:0042113	B cell activation	-6.40
	GO:0097190	Apoptotic signaling pathway	-6.12
	GO:0002285	Lymphocyte activation involved in immune response	-4.83
	GO:0001816	Cytokine production	-4.63
kMEblue	GO:0001816	Cytokine production	-35.63
	GO:0030155	Regulation of cell adhesion	-33.09
	GO:0002250	Adaptive immune response	-32.10
	GO:0002366	Leukocyte activation involved in immune response	-28.75
	GO:0019221	Cytokine-mediated signaling pathway	-26.74
kMEcyan	GO:0002366	Leukocyte activation involved in immune response	-14.65
	GO:0019221	Cytokine-mediated signaling pathway	-14.53
	hsa04060	Cytokine-cytokine receptor interaction	-13.45
	GO:0042330	Taxis	-11.47
	GO:0009617	Response to bacterium	-10.84
kMEdarkred	R-HSA-6809371	Formation of the cornified envelope	-6.80
	GO:0042552	Myelination	-3.54
	GO:0008203	Cholesterol metabolic process	-3.36
	GO:0016485	Protein processing	-2.38
	M5885	NABA matrisome associated	-2.22
kMEgreen	GO:0008544	Epidermis development	-26.58
	GO:0001942	Hair follicle development	-12.11
	GO:0048729	Tissue morphogenesis	-9.51
	GO:0008610	Lipid biosynthetic process	-6.79
	GO:0000904	Cell morphogenesis involved in differentiation	-6.75
kMElightcyan	GO:0042113	B cell activation	-10.34
	GO:0002366	Leukocyte activation involved in immune response	-8.24
	GO:0002253	Activation of immune response	-8.06
	R-HSA-1280218	Adaptive immune system	-7.80
	GO:0002250	Adaptive immune response	-7.76
kMElightgreen	GO:0070268	Cornification	-13.86
	GO:0008544	Epidermis development	-11.51
	GO:0070841	Inclusion body assembly	-6.97
	R-HSA-1461957	Beta defensins	-4.12
	GO:0033559	Unsaturated fatty acid metabolic process	-2.86
kMEmidnightblue	GO:0009617	Response to bacterium	-7.61
	GO:0002366	Leukocyte activation involved in immune response	-7.51
	hsa05150	Staphylococcus aureus infection	-6.94
	GO:0007249	I-kappaB kinase/NF-kappaB signaling	-6.77
	GO:0001816	Cytokine production	-6.55
kMEpurple	GO:0000904	Cell morphogenesis involved in differentiation	-4.37
	GO:0048729	Tissue morphogenesis	-3.87
	GO:0048598	Embryonic morphogenesis	-3.62
	GO:0022604	Regulation of cell morphogenesis	-3.52
	GO:0030155	Regulation of cell adhesion	-3.29
kMEred	R-HSA-156902	Peptide chain elongation	-7.09
	R-HSA-201681	TCF dependent signaling in response to WNT	-4.97
	GO:0033131	Regulation of glucokinase activity	-3.45
	GO:0051013	Microtubule severing	-3.32
	GO:0090277	Positive regulation of peptide hormone secretion	-3.28
kMEroyalblue	GO:0001503	Ossification	-4.32
	GO:0001501	Skeletal system development	-3.78
	hsa04514	Cell adhesion molecules (CAMs)	-3.35
	GO:0045596	Negative regulation of cell differentiation	-3.02
	GO:0010942	Positive regulation of cell death	-2.21