[Retracted] Efficacy of Platelet-Rich Plasma in the Treatment of Fractures: A Meta-Analysis
Table 2
General characteristics of studies in the final analysis ().
Study
Year
Disease
Design
Participants ()
Treatment
Male/female
Age (years)
Follow-up (months)
Main finding
Control
PRP
Control
PRP
Control
PRP
Control
PRP
Wei
2012
Intra-articular calcaneal fractures
RCT
90
85
Allograft or autograft
Allograft combined + PRP
—
18–60 (mean: 46)
72
PRP augmented the favorable outcome of allografts in the management of displaced calcaneal fractures
Daif
2013
Mandibular fractures
RCT
12
12
Bone plates + screws + PRP
16/8
17–22 (mean: 32)
6
Direct application of the PRP along the fracture lines may enhance the bone regeneration in mandibular fractures
Griffin
2013
Hip fracture
RCT
78
82
Closed fracture reduction
Closed fracture reduction + PRP
26/73
32/69
12
No evidence of a difference in the risk of revision surgery within 1 year in participants treated with PRP therapy compared with those not treated
Al-Khawlani
2014
Mandibular fracture
RCT
8
8
Open reduction + direct osteosynthesis + PRF
Open reduction + direct osteosynthesis + PRP
—
20–42
20–42
6
PRP seems to aid the acceleration of bone healing in mandibular fractures.
Samy
2015
Fracture neck femur
RCT
30
30
Cannulated screws
Cannulated screws + PRP
39/21
12–48
PRP shortens the clinical and radiation healing time of fracture neck femur
Rodriguez
2015
Bimalleolar fractures
RCT
10
10
Ilizarov fixator + concentrated bone marrow
Ilizarov fixator + concentrated bone marrow + PRP
—
52.9
54
Mean:18
PRP expedites fracture healing of the distal tibia and fibula in patients with significant comorbidities.
Ghaffarpasand
2016
Long bone nonunion
RCT
38
37
Placebo
PRP
33/5
31/6
9
Application of PRP along with autologous bone graft in the site of nonunion of long bone after intramedullary nailing results in a higher cure rate, shorter healing duration, lower limb shortening, and less postoperative pain.
Namazi
2016
Distal radius fracture
RCT
15
15
Closed reduction + percutaneous
Closed reduction + percutaneous + PRP
13/2
12/3
33.4
32.3
6
PRP may have a significant effect on the reduction of pain and amount of difficulty in functions, including specific and usual activities after intra-articular distal radius fractures.
Singh
2017
Acute diaphyseal femur fractures
RCT
39
33
Intramedullary nailing
Intramedullary nailing + PRP
37/2
32/1
32.9
30.6
6
PRP has no effect on femoral shaft fracture healing treated with closed intramedullary nailing.
Castillo
2018
Mandibular fracture
RCT
10
10
Internal fracture reduction
Internal fracture reduction + PRP
9/1
8/2
3
PRP increased the bone intensity and density in the fracture trace allowing bone regeneration and recovery in a shorter time than in patients in which it was not used.
