Computational and Mathematical Methods in Medicine

Research Article

[Retracted] Animal Models and Pathogenesis of Ulcerative Colitis

Table 2

Modeling methods of UC used in the last 30 years.
TimeModeling chemicalsCategorizationReferences
1990Human postoperative colonic mucosal supernatant+Fruend adjuvantImmunostimulation method[5]
1992Acetic acidChemical stimulation method[6]
1995Bacterial suspension made from rat colonic contentsImmunostimulation method[7]
1995Dextran sodium sulfate (DSS)Chemical stimulation method[8]
1997Colonic transplantationImmunostimulation method[9]
1998Human postoperative colonic mucosal supernatant+Fruend adjuvantImmunostimulation method[10]
1999Acetic acidChemical stimulation method[11]
1999Human postoperative colonic mucosal supernatant+Fruend adjuvantImmunostimulation method[12]
2000Human postoperative colonic mucosal supernatant+Fruend adjuvantImmunostimulation method[13]
2002Antigenic emulsifierImmunostimulation method[14]
20022.4-Dinitrochlorobenzene (DNCB)Chemical stimulation method[15]
2002Trinitrobenzene sulfonic acid (TNBS)+ethanolComposite method[16]
2003Human postoperative colonic mucosal supernatant+Fruend adjuvantImmunostimulation method[17]
2003TNBS+ethanolComposite method[18]
2004Oxazolone (OXZ)+ethanolComposite method[19]
2004Acetic acidChemical stimulation method[19]
2004DNCBChemical stimulation method[20]
2005TNBS+ethanolComposite method[21]
20051.2-Dimethylhydrazine (DMH)+DSSComposite method[22]
2005Acetic acidChemical stimulation method[23]
2005DNCB+acetic acidComposite method[24]
2006TNBS/DNCBComposite method[25]
2006DNCB+ethanolComposite method[26]
2006TNBS+ethanolComposite method[27]
2006DNCBChemical stimulation method[28]
2007TNBS+ethanolComposite method[29]
2008DNCBChemical stimulation method[30]
2008DNCBChemical stimulation method[31]
2008TNBSChemical stimulation method[32]
2008DSSChemical stimulation method[33]
2009DSS+acetic acidComposite method[34]
2009TNBSChemical stimulation method[35]
2010DSSChemical stimulation method[36]
2011DMHComposite method[37]
2011TNBS+ethanolComposite method[38]
2011DSSChemical stimulation method[39]
2012DSSChemical stimulation method[40]
2012TNBS+ethanolComposite method[41]
2013TNBS+ethanolComposite method[42]
2014TNBS+ethanolComposite method[43]
2014DSS+DMHComposite method[44]
2014DSSChemical stimulation method[45]
2014DNCB+acetic acidComposite method[46]
2015TNBSChemical stimulation method[47]
2016DNCBChemical stimulation method[48]
2017DSSChemical stimulation method[49]
2017TNBS+ethanolComposite method[50]
2018DSSChemical stimulation method[51]
2019DSSChemical stimulation method[52]
2019DNCB+ethanol+acetic acidComposite method[53]
2019TNBS+ethanolComposite method[55]
2020DSSChemical stimulation method[54]
2020DSSChemical stimulation method[55]
2021DSSChemical stimulation method[56]
2021DSSChemical stimulation method[57]