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Drug name | Modeling method | Animal | Specific modeling method | Advantages | Disadvantages | References |
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DSS | Free drinking or gavage | Rats | DSS solution free drinking for 7 d or DSS solution by gavage for 7 d. | Easy to make, high success rate, good reproducibility, lesion symptoms are very similar to human UC. | Long modeling period, influenced by many factors, unstable experimental data, difficult to make a successful and stable model. | [86–88] |
Mice | DSS solution free drinking for 7 d or DSS solution by gavage for 7 d. |
OXZ | Skin sensitization+gavage | Rats | Oxazolone applied to exposed skin for 7 d continuously combined with oxazolone gavage. | Simple operation, rapid model establishment, good reproducibility, very similar to UC in humans. | Duration of disease is maintained for a relatively short period of time and the exact mechanism is not fully understood. | [80] [89] |
Mice | Oxazolone ethanol solution combined with oxazolone ethanol solution enema. |
DNCB | Skin sensitization+enema | Rats | DNCB for 7 d, then DNCB, enema for 2 d. | Simple operation, high similarity in pathology to human UC. | More tedious operation, requires prior sensitization, inflammation is self-healing. | [90] |
TNBS | Enema | Rats | TNBS ethanol solution enema. | Simple operation, good reproducibility, shorter time to induce ulceration, longer duration of lesions. | TNBS stimulation is too severe, easy mucosal ulceration perforation, and death. | [91] [92] |
Mice | TNBS enema for 7 d. |
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