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Name | Modeling method | Animal | Specific modeling method | Advantages | Disadvantages | References |
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Colonic mucosal tissue sensitization method | Injection+enema | Rats | Injection of antigen-containing Fuchs’ antigen emulsion+enema with ethanol solution. | Longer duration of lesions; similar to human UC immunopathogenesis; suitable for screening of new drugs. | Longer modeling time; more cumbersome operation; multiple injections of antigen required to maintain sensitization. | [93] |
Rat colonic bacterial strain method | Injection | Rats | Bacterial suspensions were made from E. coli in the colon contents of healthy rats, and the suspensions were injected. | Longer maintenance of inflammation; mostly chronic inflammation. | Longer time required to prepare E. coli suspensions requires certain conditions and techniques. | [7] |
Fetal rat colonic embedding method | Surgical embedding | Rats | The fetal rat colonic was removed 3-4 cm long and surgically embedded aseptically under the right kidney pericardium in adult rats. | Animal disease, the disease model is similar to the clinical symptoms of UC. | High technical requirements; long experimental period; low success rate. | [94] |
Spontaneous animal models | Abnormal mutations in genes, selective breeding and hybridization | Serratia marcescens | Abnormalities occurring under natural conditions or genetic mutations; obtained by relying on selective breeding and hybridization methods. | The closest model to the occurrence of UC; reflects well on the development of UC and the effect of drug treatment. | Difficult to standardize control; and animals are scarce and expensive, making it difficult to apply to large-scale experiments or more in-depth studies. | [95] |
Mice |
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