MicroRNA-17-5p Protects against Propofol Anesthesia-Induced Neurotoxicity and Autophagy Impairment via Targeting BCL2L11

Figure 1

PPF treatment induces neurotoxicity in SH-SY5Y cells and downregulates miR-17-5p expression. (a) MTT assay was conducted to evaluate the survival of SH-SY5Y cells exposed to elevated concentrations (1, 5, 10, or 20 μg/ml) of PPF. (b) The level of miR-17-5p after treatment with elevated concentrations (1, 5, 10, or 20 μg/ml) of PPF by qRT-PCR. (c) The SH-SY5Y cells after treatment with 10 μg/ml of PPF for 0, 6, 12, 24, and 48 h were used for an MTT assay to determine their viability. (d) The miR-17-5p level in SH-SY5Y cell postexposure with 10 μg/ml of PPF at different time points was subjected for qRT-PCR evaluations. p, p, and p values less than 0.05, 0.01, and 0.001, accordingly.

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