MicroRNA-17-5p Protects against Propofol Anesthesia-Induced Neurotoxicity and Autophagy Impairment via Targeting BCL2L11

Figure 2

Functional experiments focusing on the impact of miR-17-5p on PPF-caused neurotoxicity. (a) By utilizing qRT-PCR, the miR-17-5p transcriptional level was examined in SH-SY5Y cells with or without 10 μg/ml of PPF treatment posttransfection with miR-17-5p or NC mimics. (b) The survival of SH-SY5Y cells was measured via MTT in the groups of mimics, , mimics, and . (c, d) FC analysis was conducted to assess the apoptosis process in the abovementioned groups. (e) Representative results of WB showed the translational levels of Bcl-2, Cleaved-caspase-3, and Bax in various groups. p, p, and p values less than 0.05, 0.01, and 0.001, accordingly.

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