Research Article
A Rule-Based Inference Framework to Explore and Explain the Biological Related Mechanisms of Potential Drug-Drug Interactions
Table 1
Summary of the potential mechanism of interaction of coadministered irinotecan and levofloxacin.
| | Irinotecan | Levofloxacin |
| Pharmacological effects | Metabolizing enzymes | CYP3A4 substrate | CYP3A4 inhibitor | Transporters | ABCB1 substrate | ABCB1 inhibitor | Biomedical features | Pharmacological (MoA) | NA | NA | Biomolecular | NA | NA | Physiological | Decreased DNA integrity | Genetic | NA | NA |
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