Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design

Figure 3

Multiple sequence alignment of theta-defensins was used in the present study. The alignment was visualized by sequence bundles. The sequence of the designed construct was also included in the alignment. Each line represents a peptide sequence that passed through the amino acid matrix introducing the peptide residue of the related site. Each sequence in the alignment block can be identified by following each line. When the bundles stack on an amino acid, a conserved site is introduced. The arrangement of amino acids was based on physicochemical properties specified at the left. At the bottom, the sequence logo also shows the conservancy of each side; the size of fonts is proportional to the entropy in the alignment column. Below the sequence logo, the sequence of the designed construct is presented by color codes.