Exploring Myocardial Ischemia-Reperfusion Injury Mechanism of Cinnamon by Network Pharmacology, Molecular Docking, and Experiment Validation

Figure 8

Taxifolin reduced arrhythmia risk after hypoxia-reoxygenation in zebrafish. Heart rate variability in zebrafish larvae. The tachocardiogram with RR intervals (the interval between two R waves, which means the heart beat cycle) in time (a, b, e, f). Nonlinear analysis and intrinsic cardiac properties (c, d, g, h). An increase in the duration of the RR intervals was observed on exposure to 1% DMSO (c, d), reflecting the occurrence of arrhythmia episodes. RRn and are two consecutive intervals. However, protection from arrhythmias was observed when exposed to taxifolin (g, h).