Upregulation of NDUFAF2 in Lung Adenocarcinoma Is a Novel Independent Prognostic Biomarker

Table 2

Univariate and multivariate Cox regression analyses of clinicopathologic features associated with OS. Abbreviations: HR: hazard ratio; CI: confidence interval.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Age	494
≤65	238	Reference
>65	256	1.228 (0.915-1.649)	0.171
Gender	504
Female	270	Reference
Male	234	1.060 (0.792-1.418)	0.694
Pathologic stage	496
Stage I and stage II	389	Reference
Stage III and stage IV	107	2.624 (1.926-3.576)	<0.001	1.758 (0.802-3.852)	0.159
T stage	501
T1 and T2	437	Reference
T3 and T4	64	2.364 (1.621-3.448)	<0.001	1.835 (1.125-2.993)	0.015
N stage	492
N0 and N1	419	Reference
N2 and N3	73	2.300 (1.614-3.278)	<0.001	1.397 (0.677-2.884)	0.366
M stage	360
M0	335	Reference
M1	25	2.111 (1.232-3.616)	0.007	1.121 (0.499-2.517)	0.782
Smoker	490
No	71	Reference
Yes	419	0.887 (0.587-1.339)	0.568
NDUFAF2	504
Low	252	Reference
High	252	1.453 (1.081-1.953)	0.013	1.538 (1.086-2.177)	0.015