Study on Computer Screening and Drug Properties of Herbs Intervening in Copper Death

Table 1

Targets related to copper death.

Gene	UniProt number	Description	Source
ATP7B	P35670	ATPase copper transporting beta	a
ATP7A	Q04656	ATPase copper transporting alpha	a
SCN5A	Q14524	Sodium voltage-gated channel alpha subunit 5	a
ATOX1	O00244	Antioxidant 1 copper chaperone	a
SOD1	P00441	Superoxide dismutase 1	a
SLC31A1	O15431	Solute carrier family 31 member 1	a
CCS	O14618	Copper chaperone for superoxide dismutase	a
CP	P00450	Ceruloplasmin	a
APP	P05067	Amyloid Beta precursor protein	a
COMMD1	Q8N668	Copper metabolism domain containing 1	a
SCO2	O43819	Synthesis of cytochrome C oxidase 2	a
FAS	P25445	Fas cell surface death receptor	a
COX17	Q14061	Cytochrome C oxidase copper chaperone COX17	a
KCNQ1	P51787	Potassium voltage-gated channel subfamily Q member 1	a
CAV3	O43497	Caveolin 3	a
AOC3	Q16853	Amine oxidase copper containing 3	a
CASP8	Q14790	Caspase 8	a
FDX1	P10109	Ferredoxin 1	b
LIAS	O43766	Lipoic acid synthetase	b
LIPT1	Q9Y234	Lipoyltransferase 1	b
DLD	P09622	Dihydrolipoamide dehydrogenase	b
DLAT	A0A2K6T1J0	Dihydrolipoamide S-acetyltransferase	b
PDHA1	P08559	Pyruvate dehydrogenase E1 subunit alpha 1	b
PDHB	P11177	Pyruvate dehydrogenase E1 subunit beta	b
MTF1	Q14872	Metal regulatory transcription factor 1	b
GLS	O94925	Glutaminase	b
CDKN2A	P42771	Cyclin dependent kinase inhibitor 2A	b

Note: a means data collected from the GeneCards database; b means data collected from the article [2].