HSimulator: Hybrid Stochastic/Deterministic Simulation of Biochemical Reaction Networks

Algorithm 3

Forward Euler method.

Input: a system of ODEs corresponding to a biochemical reaction

system, the initial state of the system with species concentrations at time , the last

time instant to be simulated and the discretization stepsize .

Output: a time series of states , providing the dynamics of the system in

terms of molar concentrations with discretization stepsize .

Pseudocode:

   initialize time and state ;

   while    do

     update ;

     update ;

   end while