HSimulator: Hybrid Stochastic/Deterministic Simulation of Biochemical Reaction Networks

Figure 1

The HSimulator graphical user interface allows easily defining, even complex, biological models in terms of customary text-based reactions. The appropriate simulation strategy can be selected and parameterised as well according to the model, although the HRSSA method offers the best hybrid simulator. The figure shows the Oregonator model [8] simulated by the HRSSA algorithm [21]. The plot shows variable abundances in logarithmic scale to illustrate the switch between the deterministic simulation of fast reactions (high abundances) and the exact stochastic simulation of slow reactions (low abundances).