Research Article

Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness

Figure 6

Prediction of seroresponse to TIV vaccination. The graph represents sample classification by means of the 207 transcripts biomarker as in Figure 2, but here the node size encodes the titer response score (bigger nodes correspond to higher indices, as displayed in Figure 5). Nodes represent subjects and the length of connecting edges is proportional to the distance between subject signatures. Node colors indicate subjects class (green for low responders and red for high responders); darker colors represent samples included in the validation set (2007-2008 TIV campaign, set #1), while lighter colors represent samples in the training set (2008-2009 TIV campaign, set #2). Node labels indicate the sample class (H for high responders and L for low responders) and the sample identifier.