Selective Phenome Growth Adapted Model: A Novel Landscape to Represent Aptamer Ligand Binding

Figure 2

Comparison of interaction maps: in the interaction maps each row represents a phenotypic contributor with interacting loci coloured blue. The columns of each interaction map represent pleiotropy vectors while the rows represent epistasis vectors. In this context pleiotropy is a single base (dark squares) affecting multiple phenotypic contributors (rows), and epistasis is multiple bases (dark squares) affecting a single phenotypic contributor (row). (a) Kauffman’s local interaction map [35] in which both the epistatic and pleotropic vectors are equal to the value of 5. (b) Kauffman’s random interaction map [35] in which the epistatic vectors are equal to the value of 5 and the pleiotropic vectors are a Poisson distribution with a mean of the value of 5. (c) Altenberg’s genome selected interaction map [34] which is highly pleiotropic at a few loci (Fisher-Pearson coefficient of 1.76) as indicated by the vertically connected dark squares. Epistatic vectors are relatively equal (Fisher-Pearson coefficient of 0.13). (d) Our novel phenome selected interaction map, presented in the current study, in which both pleotropic and epistatic vectors are relatively equal (Fisher-Pearson coefficient of 0.07 and 0.69, resp.).

(a) Local = 6

(b) Random = 6

(c) Genome selected

(d) Novel phenome selected