Automatic Lateralization of Temporal Lobe Epilepsy Based on MEG Network Features Using Support Vector Machines

Figure 1

Flowchart showing the brain-network construction of spontaneous MEG based on the Desikan-Killiany Atlas. Numbers indicate the five steps. Step : individual MRI slices were input into Freesurfer to create the brain-structure model. In this step, the skull and cortex were recognized and their boundary surfaces were determined. The single sphere-based MEG forward model was employed to calculate MEG lead fields. Step : the cortex was partitioned into regions based on the Desikan-Killiany Atlas in preparation. Step : filtered MEG recordings were projected using the inverse problem algorithm (sLORETA) on the cortices of individual participants to obtain time series for each voxel. Step : the time series were averaged over each atlas to produce 68 atlas-based time courses. Step : the connectivity matrix was constructed using the 68 atlas time courses in preparation for network parameter calculation.