Temporal Evolution of Immunity Distributions in a Population with Waning and Boosting

Figure 3

Nonmonotonic immune response mechanisms. (a, c, d) Examples of different boosting matrices for the numerical implementation of , the probability that individuals with immune level at exposure are boosted to level after exposure. The immune status is represented in and discretized on an equidistant mesh with 30 points. (b) The dotted curve represents the boosting mechanism inspired by [6], the solid curve the one inspired by [14].

(a) ANYboost

(b) Nonmonotonic boosting functions

(c) ODboost

(d) HKboost