Calculation of Free Energy Consumption in Gene Transcription with Complex Promoter Structure

Figure 1

(a) Schematic diagram for a biological prototype of gene expression. Both the activation and deactivation of a gene are complex processes, possibly involving recruitments of transcription factors, complexes, and histones as well as some modifications. (b) The biological prototype in (a) is mapped into a theoretical model of gene expression, where ON and OFF represent transcriptional active and inactive states. In (a) and (b), arrow represents transition direction between two distinct states.

(a)

(b)