Dynamical Regulation of mRNA Distribution by Cross-Talking Signaling Pathways

Figure 1

Cross-talking pathways generate typical dynamical transitions from mRNA decaying distribution to unimodal distribution undergoing the significant intermediate bimodal stage for stress genes in yeast with (). (a) Dynamical distribution of the stress gene under mild stress level equipped with , and . (b) Distribution dynamics of the stress gene under high stress level with , and . In (a) and (b), the solid circles in lines represent analytical solution, whereas the hollow circles represent the numerical result obtained by Gillespie’s algorithm. The embedded distribution dynamics are generated by the single pathway in which durations of bimodal distribution are much shorter than that generated by cross-talking pathways.

(a)

(b)