Immunokinetic Model for COVID-19 Patients

Table 1

Information of the parameters.

Par.	Description	Units	Value range	Source
	S replication rate	1/day	[2.86, 7.07]	[29]
	Maximum S	ml/(RNA copies)	[1e − 010, 1e − 09]	[29]
	Virus lysis by CD T cells rate	1/day	[0.01, 0.4]	Estimated
	Virus death rate by NK cells	ml/cell(day)	[1.2e − 11, 2e − 010]	Estimated
	Natural death rate of virus	1/day	[0.0001, 0.1]	Estimated
	CD T cells proliferation	cell/ml (day)	[50 1500]	[46]
	CD T cell activation	1/day	[0.001, 0.032]	Estimated
	CD T recruitment rate by virus lysed by NK	ml/(RNA copies) (day)	[2.1e − 06, 8.4e − 005]	Estimated
	CD T inactivation rate by virus	ml/(RNA copies) (day)	[1.1e − 10, 9.5e − 10]	Estimated
	Natural death rate of T cells	1/day	[0.001, 0.08]	[47]
	NK cells proliferation	cell/ml (day)	[7, 200]	[43]
	NK cells activation	1/day	[0.001, 0.02]	Estimated
	Inactivation NK cells rate	ml/(RNA copy) (day)	[1.1e − 06, 9.09e − 05]	Estimated
	NK cells death rate	1/day	[4.2e − 02, 0.15]	[44, 45]
	Steepness coefficient of virus lysis by T cells	—	[0.01, 1]	[43]
	Steepness coefficient of NK recruitment	—	[1e + 03, 1e + 06]	Estimated
	Fractional virus kill power	—	[9.1e − 01, 9.9e − 01]	Estimated
	Michaelis-Menten order	—	2	[47]